Milo Giambetti, the son of a notorious organized crime boss, followed his older brother Max to Port Charles when Max made him aware of a potential job opportunity. Max was employed as a bodyguard for the coffee importer and alleged mob boss Sonny Corinthos. Max convinced his boss to hire Milo and the brothers have worked together as bodyguards in the Corinthos organization for several years.
Early on in Milo's career as a bodyguard, he developed a crush on Lulu Spencer but her feelings were unrequited. Through the years, he compared all women to Lulu and believed that Sabrina Santiago could meet his standards. However, Sabrina decided to pursue a relationship with someone else before Milo had the opportunity to take her out on an official date. A few months later, Milo briefly believed his chance with Lulu had arrived. She suffered from amnesia and struggled to make sense of her life. Milo offered Lulu his friendship and his apartment during this time and they shared a kiss. However, when Lulu regained her memory she returned home to her husband.
Milo's role as Sonny's bodyguard has required him to perform a wide variety of tasks on both sides of the law. Once while he was assigned to watch over Sonny's then fiancée Connie Falconeri, he stripped at her bachelorette party and garnered the nickname "Magic Milo." He paid homage to the name by leading a group strip routine at the 2013 Nurses Ball.
While participating in the Nurses Ball, Milo met Lucy Coe and she offered him a position as the fitness director at her new spa. Milo resigned from Sonny's organization and he accepted the position at the spa. He found time to perform at the Nurses Ball again the next year where he developed a crush on a nurse. Milo believed that his father would not approve of his romantic choice and he hesitated to act on his feelings until Sonny encouraged him to follow his heart. Milo asked his crush, Epiphany Johnson, on a date and she accepted.