Chainsaw Man constructs its world on chaos, blood, and primal fears that define the lives of Devils. Every Devil of the series is an idea or a feeling that human beings are terrified of, whether it is the power over weapons or even death itself. In this dystopian ecosystem, Denji, the man-devil Chainsaw Man, has become the hero and the victim. His crude, unstable strength and his reputation as a Devil Hunter, who feeds on other Devils, endear him with fear in the universe. However, to most Devils, Denji is not only a threat but a possibility to obtain power or even to avenge old scores.
The life of Denji since the introduction of Chainsaw Man has been the object of multiple Devils who want to kill him due to personal, political, or existential motives. Others were driven by the fear of his powers to wipe Devils off the earth, and others wanted an avengement for those that he consumed. Since the Control Devil and the Darkness Devil, Denji has had to reckon with unrelenting enemies — more dangerous and more psychologically complicated than the previous. In the list below, the top 10 strongest of the Devils who have wished to kill Denji are placed in order of their abilities, motives, and the danger they represented to the Chainsaw Man himself.
Top 10 Strongest Devils Who Have Wanted to Kill Denji in Chainsaw Man
10. Eternity Devil

The Eternity Devil was introduced in the Eternity Devil Arc, where it imprisoned Denji and his fellow Public Safety Devil Hunters in a never-ending loop of a hotel. It embodied the terror of eternal damnation - an idea that sent even experienced hunters mad. It was not one of the strongest Devils physically, but its mental strength was enormous. It despised Denji due to desperation; it would rather kill him because the Chainsaw Man form of Denji was capable of ending its misery. Ironically, the reckless courage and readiness to go on a fighting spree all night long led Denji to defeat the Eternity Devil. It is not a god-level opponent but the start of the Devils actively trying to kill Denji.
9. Katana Man (Human-Devil Hybrid)

One of the first to personally take an interest in killing him was Katana Man, a hybrid like Denji. Katana Man, motivated by the revenge for the death of his grandfather, a Yakuza leader who was killed by Denji, used human wits with the destructive power of the Katana Devil. His extreme hate towards Denji sent him on several fights that demonstrated his prowess, speed, and resilience. But the powers of Chainsaw Man eventually got the better of Denji. His defeat notwithstanding, Katana Man was one of the first and most emotional threats in the show due to his determination to kill Denji.
8. Bomb Devil (Reze)

Reze (the Bomb Devil hybrid) first appeared as the love interest of Denji but later turned out to be an assassin who was tasked with killing him. When she became the Bomb Devil, she demonstrated her destructive explosive abilities, that she could level out a squad in a few seconds. It was her purpose to kill Denji and bring his heart back to her superiors. Her human feelings had complicated her mission despite her strength, agility, and intelligence, resulting in hesitation and subsequent defeat. Reze is among the most tragic and deadly assassins who have ever attacked Denji and is filled with emotional nuance and deadly ability.
7. Gun Devil

The Gun Devil is one of the most notorious characters in Chainsaw Man. Being the embodiment of the universal fear of guns and large-scale killings, this Devil was almost a doomsday weapon. It killed millions within seconds, which made it one of the strongest Devils ever to have lived. The Gun Devil did not actually hate Denji directly but rather indirectly—organized by political figures and contracts in an attempt to project this hatred towards Chainsaw Man. Using its fragments, both Devils and humans were controlled to hunt Denji down, which means that it was an important indirect threat affecting several storylines.
6. Hell Devil

One of the most metaphysical dangers to the world of the Chainsaw Man is its Hell Devil, which represents the notion of damnation. It can bring creatures straight to Hell, the place of primitive Devils. When Denji and his crew were taken to Hell, the Hell Devil attacked him indirectly by providing a setting where the Darkness Devil would strike. Although it seldom has personal malice, it can confine Denji to realities that mortals cannot even imagine, and that is why it is one of the most dangerous creatures in the world.
5. Control Devil (Makima)

In her human form as Makima, the Control Devil is, perhaps, the most manipulative creature Denji has ever met. She wanted to kill and, at the same time, control Denji because she was obsessed with the idea of Chainsaw Man itself. The plan of Makima, unlike others, was psychological and systemic. She desired to destroy the human mind of Denji to manipulate the Chainsaw Man in him and to use his strength to rebuild the world. Her power to manipulate Devils and humans by use of contracts, as well as her godlike control over events, made her one of the greatest enemies in the series.
4. Darkness Devil

The Darkness Devil is one of the most dreaded creatures of Chainsaw Man because it is the primitive fear of darkness. Its very presence causes despair and madness because it was never killed in history. Its power, which could not be comprehended, was demonstrated during the Hell sequence, when it confronted Denji and other Devil Hunters. Although it never stated that it had a goal of killing Denji himself, it was motivated to do it by the underlying desire to kill lesser beings. The pure cosmic power of the Darkness Devil and his sense of horror make him one of the most dangerous enemies of Denji.
3. Falling Devil

Another tremendously powerful creature, which was added later in the manga, is the Falling Devil, which is the primal fear of falling physically and emotionally. Having the power to control gravity and emotion, it brought much destruction in its pursuit of Denji in the scheme of the Famine Devil. The Falling Devil, unlike the Darkness Devil, had a reason to do it, attacking Denji to accomplish the greater evil ends. Her sheer physical superiority and mental fight caused her to be one of the most dreadful enemies Denji had to deal with, as she almost killed him several times.
2. Death Devil

The Death Devil represents the greatest fear: death. Being one of the Four Horsemen, its power is even beyond the ability of most Devils. Its lore, though not yet fully disclosed in the anime, makes it a creature that can destroy all life, even other Devils. This wish to murder Denji is based on the existential danger that Chainsaw Man represents—his capability to remove Devils out of the world is contrary to the natural law that the Death Devil embodies. This imminent conflict is one of the most expected in the Chainsaw Man story.
1. Chainsaw Man (Denji’s Own Devil Form)

Ironically, the most perilous Devil who has sought to kill Denji is his alter ego, his own Chainsaw Man in him. This animalistic display of Pochita symbolizes the naked instinct of annihilation, regardless of Denji being human or not. At times, the sheer greed for blood and mayhem of this creature conflicts with the need of Denji to live a normal life. Literally and metaphorically, Denji is the worst foe to himself, the part of him that consumes and destroys other Devils without any hesitation. The Chainsaw Man figure is the highest since it is a symbol of the climax of power and the highest level of inner struggle in the series.
The hierarchy of Devils in Chainsaw Man is not only based on strength but also on the complexity of fear itself. Emotional rivals like Reze and Makima and god-like figures like the Death Devil all show a new aspect to the cursed life of Denji. Each conflict brings Denji one step closer to realizing his duality himself, as a man pursued by dreams and a Devil that everyone fears. As Chainsaw Man keeps on developing, there is one truth: in a world where fear is the order of the day, the mere existence of Denji makes sure that the cycle of the Devils hunting the Devils will never end.