Despite having run for only 6 episodes, Takopi's Original Sin is one of the most beloved anime of the year. The twisted tale of the friendly Takopi trying to get involved in the lives of young children leads to shocking events that have obtained a permanent place in the minds of viewers.
Since the series has now ended, fans may be desperate to search for similar stories. Here are 7 manga that are widely considered to be more depressing than Takopi's Original Sin.
Manga that are sadder than Takopi's Original Sin
7) Nana
Nana is an iconic shoujo manga that is considered to be a staple of its genre. At first glance, it seems to be a dreamlike tale of two women moving to Tokyo to chase after their dreams and fall in love. However, the story soon disillusioned its viewers by hitting them with a dose of harsh reality.
Nana does not shy away from exploring difficult themes such as abuse, drug addiction, heartbreak, and betrayal. The imperfections of different individuals are highlighted, making them extremely frustrating but also deeply relatable and human. As a result, the series will create a long-lasting impact just like Takopi's Original Sin, though it will be far from a smooth ride.
6) Blood on the Tracks

Blood on the Tracks is considered by most readers to be one of the most uncomfortable manga ever made, and for good reason. The story focuses on a boy named Seiichi who is emotionally manipulated and controlled by his mother, Seiko. Despite wishing to grow up and experience the joys of youth, he is chained in place, making for a haunting experience.
Unlike Takopi's Original Sin, Blood on the Tracks is slow-paced, gradually dissecting the psyches of its characters and the terrifying love of a parent. As a result, it is horrifying, distressing, and unique from all other manga.
5) To Your Eternity
Just like Takopi's Original Sin, To Your Eternity may seem to be a fascinating and fantastical tale initially. It follows Fushi, a mysterious being that can change its form based on its surroundings and experiences. What starts as an exploration of different cultures and time periods, however, soon turns much darker.
With every new life Fushi inhabits, it encounters countless tragedies and losses. Therefore, though a being beyond understanding, it gradually grows accustomed to heartbreak. With a cast of memorable side characters who briefly accompany Fushi during their short life spans, the hardship of immortality is made painfully apparent.
4) Fire Punch

While Chainsaw Man catapulted Tatsuki Fujimoto into fame, Fire Punch helped build the core of his fanbase. Set in a bleak and dystopian world with constant snow and famines, the manga follows Agni, a man cursed with eternal flames and unable to die. Determined to gain revenge against those who killed his sister, Agni sets off on an unrewarding journey that plunges him into the unending darkness of humanity.
Fire Punch is a manga that deals with several questionable themes such as cannibalism, incest, genocide, and religious fanaticism. While Chainsaw Man presents its story in a charming manner, Fujimoto does not attempt to do the same with Fire Punch, instead testing the limits of how brutal and sad a shonen manga can be. Hence, fans of Takopi's Original Sin will also deeply resonate with it.
3) Your Lie in April
Your Lie in April is a manga that needs no introduction. Considered to be a legendary tale of music and love, the story follows Arima, a boy with a traumatic childhood. Though once a genius pianist, the shadows of his past push him away from the instruments. However, the protagonist's life is filled with color when the cheerful violinist Kaori motivates him to re-enter the world of music.
While Your Lie in April is a beautiful tale of growth and melodic tunes for the most part, its conclusion is one of the most heartbreaking in both anime and manga. Kaori's illness and her letter to Arima deal an emotional blow that many fans are yet to recover from.
2) No Longer Human

No Longer Human is one of the most beloved Japanese novels of all time, detailing the life of the author, Osamu Dazai. While the manga has two adaptations, one by Junji Ito and the other by Usamaru Furuya, the latter is a more depressing tale compared to the former's horror-based approach. Furuya’s No Longer Human offers a modern take on the intriguing and self-destructive protagonist, Yozo Oba.
His inability to connect with society, paired with the shocking developments in his life, perfectly captures the feeling of existential dread that Dazai's book showcased. The series of unfortunate events, where things keep going from bad to worse, mirrors Takopi's Original Sin, though with a more mature tone.
1) Goodnight Punpun
Most fans of Takopi's Original Sin consider Goodnight Punpun to be the manga most similar to it, and this is true to an extent. Goodnight Punpun follows Punpun, a bird-like creature with a troubled upbringing. From a turbulent home life to the complexities of adolescence and the toxic presence of a girl in his life, Punpun's coming-of-age tale is a depressing rollercoaster that goes from one tragic event to the next.
Punpun himself is very similar to Takopi, with both being naive and emotionally unaware of their surroundings. However, while Takopi's Original Sin decides to take a more surreal tone in its storytelling, Goodnight Punpun is grounded, brutally honest, and unrelenting. It offers no relief to the reader from beginning to end, earning it the label of “the most depressing manga that should never be made into an anime.”