4) Katherine Heigl and Seth Rogen

Katherine Heigl being "sexist" against Knocked Up made her relationship with Seth Rogen sour. When Rogen called her comments hypocritical, considering she starred in the movie too, the beef endured for years. While Heigl eventually apologized and regretted her phrasing, Rogen pointed out after a 2021 interview that their working relationship never recovered.
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Edited by Sarah Nazamuddin Harniswala