4. Slade’s Mirakuru-Induced Betrayal

Once Oliver's devoted mentor, Slade, gives in to the Mirakuru's insanity in Arrow (S2E23), thinking Oliver picked Sara over Shado. His revenge is extremely personal because of his tragic transition from ally to enemy. His reputation as the show's ultimate villain is cemented the instant he betrays Oliver by promising to take everything from him. He starts his unrelenting campaign against his old friend with the terrifying question, "You think I won't hurt you?"
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Edited by Debanjana