20) Reese Witherspoon - Scream
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Reese Witherspoon was rumored for a role in Wes Craven's influential horror film Scream with Sidney Prescott, but the role didn't do much to fit the kind of image she would have to reestablish for herself at the time. This went to Neve Campbell, who plays the resilient heroine in a defining moment of the genre. Witherspoon's decision did not deter her, as she quickly became an iconic success in Legally Blonde.
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Edited by Apoorva Jujjavarapu
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