Netflix’s Little Brother starring John Cena casts multiple new actors in major roles, entire list revealed

The cast for Netflix's new comedy film, Little Brother, has just expanded as a group of fresh comedic talents has joined the central duo of John Cena and Eric Andre.

The new cast additions include Sherry Cola, Ego Nwodim, Chris Meloni, Ben Ahlers, and Caleb Hearon. They will be part of this exciting project, initially announced at the end of 2024 as being in early development at Netflix. The screenwriting duo of Andrew Mogel and Jarrad Paul (Huge in France, The Grinder) was then attached to this feature film.

Later, in April 2025, Matt Spicer was announced as the director for this project. Spicer made his feature directorial debut with 2017's Ingrid Goes West, a dark comedy starring Aubrey Plaza and Elizabeth Olsen. It earned him the Waldo Salt Screenwriting Award at the Sundance Film Festival, followed by the Best First Feature award at the Film Independent Spirit Awards. So, the Netflix film is supposed to be his follow-up feature project.

The official logline for Netflix's Little Brother reads:

"A famous real estate agent's life is disrupted when his eccentric little brother unexpectedly reappears."

With this project, John Cena and Eric Andre reunite after the infamous episode of Andre's late-night parody talk show, where Andre suffered a concussion while performing a comedic stunt. Their new collaboration will pair them with many new faces, who have been proving their comedic chops in the last few years or more.

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Netflix’s Little Brother: The entire cast list revealed so far

John Cena

John Cena has made a successful transition from professional wrestling to acting, having starred in a variety of projects, proving his acting range. After starring in Prime Video's Heads of State with Idris Elba, Cena made a brief cameo in DCU's Superman as Peacemaker. He has starred in many comedy projects like Barbie (2023), Ricky Stanicky (2024), Blockers (2018), Vacation Friends (2021), and more.

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Eric Andre

The Little Brother star Eric Andre is widely known for his talk show, where he invites celebrities to be part of his elaborate parodies. In 2021, he starred in Bad Trip, a comedy feature film that he co-wrote. He was recently seen in the cast of the MCU series, Ironheart. Previously, he has been part of comedic shows like Man Seeking Woman, The Righteous Gemstones, Disenchantment, and more.

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Sherry Cola

Sherry Cola was recently seen in the Netflix comedy series Nobody Wants This, playing Ashley. She has otherwise starred in comedic films such as Joy Ride (2023), Shortcomings (2023), Sick Girl (2023), and A Family Affair (2024). Her most popular role has been Alice Kwan in the Freeform series Good Trouble.

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Ego Nwodim

Ego Nwodim has been a key member of the Saturday Night Live cast since 2018. She was recently seen in Rian Johnson's investigative thriller series Poker Face. Otherwise, she has starred in shows like Mr. Throwback, Brockmire, Love Life, Good Times, and more. Her film credits include Lyle, Lyle, Crocodile (2022) and Scrambled (2023).

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Chris Meloni

Chris Meloni, soon to be seen in Little Brother, is primarily known for playing Detective Elliot Stabler in the Law & Order series. His other television projects include Happy!, Underground, Maxxx, Captain Fall, and Harley Quinn.

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Ben Ahlers

Ben Ahlers has starred in the second season of The Last of Us. He has also been a key member of the cast of The Gilded Age as Jack and When the Streetlights Go On as Brad.

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Caleb Hearon

Caleb Hearon, who has been cast in Netflix's Little Brother, has previously starred in Sweethearts (2024), I Used to be Funny (2023), and Jurassic World: Dominion (2022). He was also seen in shows like Overcompensating, Mr. and Mrs. Smith, and Work in Progress.

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Little Brother is yet to receive an official release date.