Dave Coulier, the actor known for playing the role of Uncle Joey in Full House, has revealed a new cancer diagnosis just months after enjoying remission from non-Hodgkin lymphoma. The actor, who is 66 years old, spoke about the new cancer diagnosis in an interview with TODAY.After what he thought was a common upper respiratory infection, Dave Coulier discovered a "golfball-sized" enlarged lymph node in his groin in late 2024, which marked the beginning of his cancer journey. His biopsy confirmed that it was Stage 3 non-Hodgkin lymphoma.He publicly disclosed the diagnosis in November 2024, outlining how swiftly the crisis progressed and how the news affected his wife, Melissa. Dave Coulier claimed that chemotherapy was difficult and frequently left him uncertain of how his body would react in between sessions. He was also troubled by his family history; he had lost his mother, sister, and niece to breast cancer in the past, and another sister was currently fighting the illness. But by April 2025, following months of treatment and follow-up biopsies, experts informed him that he was cancer-free.Following the report, he said:"[My wife] and I waited for a week to get the biopsy results back, and there is no sign of cancer. One of the few times in my life when ’zero’ has been a great number to hear."Dave Coulier's second cancerSeven months after announcing he was cancer-free, Dave Coulier walked in for a routine PET scan, part of his post-lymphoma monitoring plan. During one of these scans in October 2025, physicians found something unusual near the base of his tongue. He had no symptoms at all. Then he found out about the cancer after tests and scans.His initial response to the diagnosis was "a shock to the system." He said:“To go through chemotherapy and feel that relief of whoah, it’s gone, and then to get a test that says, well now you’ve got another kind of cancer ... it is a shock to the system.” The initial biopsy was inconclusive, indicating no cancer cells. "It was a really tough year, chemotherapy was grueling. A couple of months ago, I had a PET scan, and something flared on the scan. The doctor said, 'We don't know what it is, but there's something at the base of your tongue.'"Dave Coulier continued:"It was very painful. It's like if you bit your tongue, but the pain just lasted every single day. We thought, 'This is great. We're still not sure what it is, but there aren't any cancer cells."By his next scan, the region had increased in size, which prompted a second biopsy, this time including the removal of a larger portion of the tongue. The test results were positive for cancerous cells:“They said it’s totally unrelated to my non-Hodgkin’s lymphoma. This is a new cancer. ... I said, 'Are you kidding me?'"He added:"They said it could stem from having an HPV virus up to 30 years ago. A lot of people carry the HPV virus, but they said mine activated and turned into a carcinoma."Coulier's Treatment: Radiation and recoverySome good news from Dave Coulier's side, as he says:“We found it early enough where it’s very treatable. ... It’s got a 90% curability rate. The doctor said the prognosis is good, but we're going to start radiation immediately."The Full House actor is now having 35 radiation treatments, from Monday to Friday, until the end of 2025. While radiation is less physically demanding than chemotherapy, he notes it comes with its own issues, nausea, “radiation brain,” and lingering tongue and facial pain from the biopsy:"It’s a whole different animal than chemo. It doesn’t feel as aggressive, but there are still side effects. That's not 100% healed yet."Being the humorus person that he is, he jokingly said:"My joke usually is ... I’m doing really well for a guy with cancer.”Since his radiation treatments are from Monday to Friday until the end of 2025, he said: "I get to start the new year saying, I finished radiation yesterday! It's kind of serendipitous."Having to deal with two cancers in the same year has taken a toll not just on him but on his family as well. Speaking about it, Dave Coulier said:“It’s emotional. It’s psychologically draining. It’s also a big drain to my wife, Melissa, which is the biggest drain on me, seeing how this affects her.”Coulier even mentioned that he will remain "cautiously optimistic. I'm going to get on the other side of this."Speaking about the experience of dealing with cancer twice in a year and getting lucky, as it helped diagnose the other:“The silver lining here is that I had cancer, which helped me detect my other cancer. It seems crazy to be making that statement, but it’s true."Dave Coulier added, speaking about listening to his doctor's advice on getting PET scans:"Had I not gone in and listened to my doctors and made sure that I got that PET scan to follow up, we would have never found this carcinoma ... and I could be in a world of hurt. This could have progressed immensely, and I would be in trouble.”As Dave Coulier proceeds with his treatment, his grandson, Chance, is making the battle easier. Coulier is now an advocate for early testing. He said:“I never wanted to be the poster boy for cancer, but I’m happy to do it. How the heck can I not take this moment to use my voice to say to people, 'Hey, early detection saved my life, and now early detection saved my life again."Stay tuned to Soap Central for more information.