In late 2025, the passing of film director Rob Reiner and his wife, Michele Singer Reiner, shocked the film industry and the world. Their 32-year-old son, Nick Reiner, has since been arrested and charged with murdering both of his parents over the stabbing deaths of both found in their Brentwood home on December 14. In the developments of the case that are playing out in court, new information has come to light regarding Nick's mental state prior to the event.What has attracted particular attention, however, is the suggestion of a possible change in Nick’s medication for schizoaffective disorder, which might have contributed substantially to Nick’s deterioration just prior to the killings. This has been widely cited in recent media reports and is likely to become a focus of Nick’s defence.Nick Reiner’s Mental Breakdown & The Medication ChangeIn the period prior to December 14th, Nick Reiner had also been under treatment for the psychological condition of schizoaffective disorder. This disorder combines aspects of both schizophrenia and an affective disorder such as depression or mania. Nick had also been under medication for schizoaffective disorder for several years. His medications had stabilized his disorder.According to sources interviewed with investigative publications, the changing nature of the treatment he got about a month prior to the murders is as follows. His psychiatrists changed/switched the medication he was taking, although the medication he was given is not revealed. This sudden change in treatment is later noted in the case as leading to a dramatic change in Nick's behavior.Following the adjustment, sources report that Nick was becoming more agitated and erratic. His loved ones reported the ominous changes in him, while his friends even reported that he was no longer behaving in a manner typical for him. When the events leading to the murder culminated in the killings themselves, sources indicate that Nick Reiner seemed to be detached from reality. Nonetheless, there is no report that he was subject to any kind of forced mental evaluation at this critical juncture.The events surrounding his treatment have become virally contagious due to their potential influence over Nick Reiner’s legal defence. His lawyers are likely to plead that his shift in prescription triggered a psychological breakdown rendering him incapable of comprehending his own legal actions as governed by California law. As the process unfolds, with arraignment reschedules and changes in representation, it seems the discussion involving mental health, medication management, and legal accountability remains at the forefront.