General Hospital Spoilers VIDEO Sneak Peek, September 22-26: Saying goodbye to Monica Quartermaine

Here is your General Hospital spoilers sneak peek video for the week of September 22-26, 2025.

What to expect on General Hospital

Is that really Nathan West? | Image: ABC

Life and death collide in Port Charles this week as a man appears in the ER who looks exactly like Nathan West (Ryan Paevey). Anna (Finola Hughes) and Dante (Dominica Zamprogna) need to get to the bottom of things without alerting Nathan's family to what is going on.

However, Britt (Kelly Thiebaud) will now be working in the ER again, so it might be hard to keep this news from her that her brother could be alive. Liesl (Kathleen Gati) would be in more shock than she was when she saw Britt, considering that two children returning from the dead over the course of two weeks is just a bit too much.

However, Nina (Cynthia Watros) appears overjoyed, so she may learn about her brother/cousin and have 'Jay' back in her life.

Meanwhile, Britt realizes that her new Pascal-free life in Port Charles is not all she thought it would be. She finds a package on her bed with her meds, so she knows that whoever she was working for is still out there.

Mourning Monica

Jason and Laura at Monica's funeral | Image: ABC

News about Monica's (the late Leslie Charleson) death spreads throughout Port Charles and General Hospital, with Lucy (Lynn Herring) learning what happened when she pays a visit to Monica's house and drives Tracy (Jane Elliot) bananas.

Port Charles citizens gather at the church to pay their respects to Monica. Jason (Steve Burton) and Tracy look like they may lose it, but they have to get through the day and the agonizing eulogies — and so do we. Expect flashbacks galore, going back nearly half a century, as a legendary soap opera character is laid to rest.

The Quartermaine crypt

General Hospital's Tracy finds a stranger in the crypt | Image: ABC

Monica will intern with the rest of the Quartermaine clan, joining her husband Alan (the late Stuart Damon), her son AJ (Sean Kanan), and her daughter Emily (Natalia Livingston). When Tracy goes to visit the mausoleum after the funeral, she finds a mysterious woman looking at her mother's name, Lila Morgan Quartermaine (the late Anna Lee).

The woman is played by One Life to Live legend Erika Slezak, but it doesn't look like she will be playing Lulu's (Alexa Havins) boss, Victoria Lord. So, how is this woman connected to Monica?