ABC Grey's Anatomy has provided television with some of the most chilling deaths ever.
These were not only sad moments. They were unforgettable. There was heartbreak in connection with each loss. Some were abrupt and appalling. Others were slow and painful. Fans will not forget the scenes when George O'Malley was struck by a bus, Derek was killed in a car accident, and Lexie Grey was a victim of a plane accident.
Such scenes were emotionally devastating. Denny Duquette, who died during the surgery to the heart, and Mark Sloan, who died following the same car accident that claimed the life of Lexie, left fans heartbroken. Meredith also lost her mother, Ellis Grey. The 9 death cases listed below are painful to remember and remain at the heart of Grey's Anatomy.
Disclaimer: This article contains the writer's opinion. Readers’ discretion is advised.
The list of the 9 most chilling deaths in Grey's Anatomy that still break our hearts is given below
9. Mary Portman

Mary Portman (Mandy Moore) was one of the Grey's Anatomy patients who survived a shootout at the hospital in the season 6 finale. She required surgery to reverse her colostomy and did not come back to the hospital until six months later to undergo the surgery. While the surgery went well, Mary never opened her eyes after being put under anesthesia and eventually had to be removed from life support.
Autopsy did not disclose any apparent reason why she did not wake up. Mary died, and a pathologist conducted an autopsy. Bailey was there too. She continued to quarrel with the pathologist as she loved Mary. She felt that something was wanting in the pathologist. However, ultimately, they were not able to know the reason behind Mary's falling into a coma. Bailey was forced to inform Bill that she was unaware of the reason why Mary never awoke after the surgery.
Also Read: Find out more about Mary Portman's death!
8. Adele Webber

Adele Webber on Grey's Anatomy developed Alzheimer's disease in season 7. Adele and her husband, Richard, suffered as a result of her gradual downfall on the show. Adele fought memory loss until she finally died of a fatal heart attack in season 9.
Her passing was tragic because it mimicked the agony of watching someone you love lose them slowly over the years. Adele's character represented the struggles of those who deal with dementia and the devotion of the caretakers.
7. Dylan Young

Season 2 episodes 16 & 17 of Grey's Anatomy included Dylan Young (Kyle Chandler) as a guest star. Dylan Young was one of the top officers on the Seattle Police Department Bomb Squad, who was killed when a bazooka round projectile exploded as he was carrying it. His heroism unfortunately led to tragedy as the bomb went off and killed him instantly. Dylan's untimely death shocked the fans.
He gained everyone's admiration despite his brief tenure on the show due to his selflessness and readiness to put others before himself to save them. His death was an unforgettable and sad episode in the history of the show and the risk that first responders face.
6. Denny Duquette

A Grey's Anatomy patient named Dennis Duquette enthralled actors and viewers with his passionate relationship with Izzy Stevens. He appeared to be looking forward to the future after experiencing congestive heart failure and receiving a transplanted heart.
However, a blood clot killed him soon after he proposed to Izzy. His unanticipated and tragic death occurred hours after he proposed to Izzy and is still one of the most dramatic and unforgettable scenes on the television show. Denny's story depicted life's fragility even after the medical miracles.
5. Andrew DeLuca

Andrew DeLuca was a conscientious Grey's Anatomy doctor who also dealt with mental illness. He took the law into his own hands to save a victim of human trafficking without the assistance of the police during season 17. He subsequently put himself in grave danger by getting stabbed during the investigation.
Despite initially appearing to be recovering following surgery, the complications that included cardiac tamponade took his life. His death shocked his fans and illustrated his bravery and his dedication to seeking justice at the expense of his own life.
4. Lexie Grey

Lexie Grey was the half-sister of Meredith Grey and an expert surgeon on Grey's Anatomy. She died in one tragic scene on the show. Lexie got injured and was pinned under wreckage after she got caught up in an airplane crash along with other surgeons on their way to operate. She was seriously injured and unable to move.
Mark Sloan, her boyfriend, remained beside her and said he loved her. Lexie realized she would die, and she did with a smile on her face, imagining her future with Mark. Her death affected the actors and the audience alike. Lexie's story remained close to the hearts and screens of the audience, revealing the strength and potency of love and grief in the harsh world of the hospital.
3. Mark Sloan

Mark Sloan was Lexie Grey's charismatic boyfriend and an MD on Grey's Anatomy. Surviving the plane crash, Mark's injuries were internal. He fell into a coma and remained alive on life support. Mark did not get better, and after 30 days without any indication of waking up, life support was withdrawn. His fans and friends took his passing hard.
Mark's passing was heartfelt due to his love for Lexie and his strong friendships. The hospital renamed itself Grey Sloan Memorial Hospital in his and Lexie's memory. Mark's passing was pivotal and altered the course of the show forever.
2. George O'Malley

George O Malley was a founding doctor in the television series Grey's Anatomy. George was also generous and would make himself second to others. He volunteered to work in the army as a trauma surgeon. George rescued a lot of lives in the course of service, but suffered a severe injury. He drove to rescue somebody and was run over by a bus, where he sustained fatal wounds.
His demise came as a shock to the fans since he was a good-hearted person. The death of George was disappointing and surprising. It portrayed how even the heroes deal with bitter realities. His tale has been an unforgettable one to the show and has also reminded the audience of the value of life.
1. Derek Shepherd

Derek Shepherd was the real love of Meredith Grey and a well-known neurosurgeon in the show, Grey's Anatomy. His passing caused a shock to the whole world of Grey's. Derek had been in a car crash while rushing to the rescue of other people. His condition deteriorated despite emergency efforts. Meredith had to make a bitter decision to turn off his life support.
Derek's passing crushed the hearts of his fans because he was compassionate, smart, and universally liked. The loss that took place altered the course of the show. The story of Derek is remembered because it is one of the strongest and touching episodes of Grey's Anatomy.
These deaths from Grey's Anatomy changed the show and its characters. Each one was challenging and offered a unique experience.
In their farewell and selfless deeds, respectively, Mark and George displayed a great deal of love and courage. These scenes weren't just included in the narrative. They served as powerful reminders of the inseparability of love and defeat. Grey's Anatomy has progressed, but these stories have remained with all the viewers.