Brilliant Minds Season 2 Episode 1: Release date news, time, streaming details and more about the premiere

Brilliant Minds Season 2 Episode 1 airs Monday, September 22, 2025, at 10/9c on NBC, with the premiere episode streaming the following day on Peacock. The premiere episode has been titled Phantom Hook and will see Dr. Oliver Wolf's continuation as he battles both his professional life as a physician and personal epiphanies.

The second season continues just after Season 1's cliffhanger, when Oliver had learned about his father, Dr. Noah Wolf, being alive and suffering from an undiscovered neurological disorder. Brilliant Minds Season 2 takes off from this cliff-hanging finale since it brings along some new individuals and patient cases as well.

Brilliant Minds Season 2 Episode 1 release date and time

Brilliant Minds Season 2 Episode 1 premieres on September 22, 2025, at 10/9c on NBC. As in the initial season, each episode will be available to stream on Peacock the following day.

Season 2 retains its Monday night timeslot, providing viewers with a weekly window of time in which to catch up and discover what's next.

Where to watch Brilliant Minds Season 2 Episode 1

Episodes will initially appear on NBC before they appear on Peacock, which also has the entire first season. This allows an audience to have the choice to watch live or to binge on demand.

Season 2 repeats the trend, and it is quite easy to broadcast and stream.

Cast and new characters in Brilliant Minds Season 2

Zachary Quinto reprises his role as Dr. Oliver Wolf. Tamberla Perry, Ashleigh LaThrop, Alex MacNicoll, Aury Krebs, Spence Moore II, Teddy Sears, and Donna Murphy are also back.

There are new cast members in Season 2: John Clarence Stewart as Dr. Anthony Thorne, an ER doctor with OCD. Brian Altemus as Dr. Charlie Porter, a neurology resident who is also competitive. Bellamy Young as Dr. Amelia Frank, the clinical director of a long-term mental health hospital. Al Calderon is a recurring character.

These cast members should have an effect on the hospital and personal politics of Bronx General Hospital.

Season 1 recap, leaping into Brilliant Minds Season 2

Season 1 established the groundwork for the combination of medical drama and personal history comprising the series. Dr. Oliver Wolf, portrayed by Zachary Quinto, was brought in as a neurologist at Bronx General and had to contend with amazing cases based on real cases Dr. Oliver Sacks treated.

Every episode had unconventional and intricate neurological disorders, ranging from patients living in distorted realities to patients suffering from memory and identity crises, all while illustrating how the disorders affected both patients' lives and Oliver's career as a physician.

But aside from the medical mysteries, the season delved into Oliver's internal conflicts. Viewers watched him navigate the burden of family history, loss, and the work pressure of a doctor performing in a high-stress hospital setting. Friendships with peers like Dr. Indira Joseph (Tamberla Perry) and residents like Dr. Bruno (Spence Moore II) brought support and friction into Oliver's life and contributed to his development throughout the season.

Episode 1: "Phantom Hook"

The season opener, Phantom Hook, brings Oliver and his staff back into focus, as well as setting up the season. The name is one of the featured medical cases in the teaser, but the show also begins building Oliver's complicated family background.

Season 2 utilizes this one to bring in patient-centered storylines and returning character storylines.

What to expect from Brilliant Minds Season 2

The show continues to find inspiration in neurologist Dr. Oliver Sacks' work, and the peculiarity of neurological cases remains the highlight, but these are combined with personal anecdotes. Season 2 combines the above, where hospital life pressures, the struggle of patients, and Oliver's increasing relationship with his father overlap.

Brilliant Minds Season 2 Episode 1 airs on September 22, 2025, at 10/9c on NBC and is available to stream the following day on Peacock. The season picks up from where Season 1 ended in a cliffhanger, adds new cast, and sees patient storylines teased in the teaser.