Find out upcoming Fox medical comedy Best Medicine's latest casting announcement and it will definitely blow your mind

Fox's medical comedy Best Medicine received a new infusion of talent that is bound to attract the attention of both fans and industry observers. On July 7, 2025, co-stars Josh Charles, Abigail Spencer, and Josh Segarra were officially announced as new cast members.

This casting news makes Best Medicine one of the more prominent scripted developments that Fox has in store at this point. As a point of reference, the series is a comedy adaptation of one of the most famous British shows of all time, Doc Martin.

The show is about Dr. Martin Best (performed by Josh Charles), a surgeon, socially awkward genius who leaves a large practice in Boston to come back home to a seaside city in upstate New York and soon discovers he no longer fits there either, is scheduled to start shooting in the summer of 2025.

Abigail Spencer’s Role

Abigail Spencer, best known for her work on the hit series Grey’s Anatomy (2017–2022), brings valuable experience from the world of medical drama—experience that could add depth and richness to the comedic tone of Best Medicine. While her exact role in the project remains under wraps, her presence is sure to make an impact.

Her casting is an indication that Fox wants to give the show the weight of a series rooted in the truth of authentic medicine and dramatic believability, with the rest of the focus on the comedic tone. Spencer, again to the delight of fans of Grey, can add depth to his performance as an actor that could otherwise have given a simple comedic role a prominent fill.

Josh Segarra’s Entry

Meanwhile, Josh Segarra, whose credits include Sirens and Abbott Elementary, is stepping into the mix with his blend of comedic timing and dramatic weight. At 39, Segarra joins the cast as a series regular, positioned “opposite” Josh Charles, suggesting a substantial role, perhaps a colleague, friend, or local foil to Dr. Best. Segarra’s track record suggests he can handle roles that balance humor with the occasional emotional beat, making him a smart addition to Best Medicine.

What This Means for Best Medicine

With both Spencer and Segarra on board, the show has assembled a well-rounded ensemble. Josh Charles anchors the lead, while Spencer and Segarra flank him with complementary strengths: Spencer’s medical drama background and Segarra’s comedy chops.

For fans of the Doc Martin format, which hinges on character-driven comedy and interpersonal friction; this trio paints a promising picture. From a production standpoint, Deadline confirms that filming will take place in a quaint New York coastal town this summer. This aligns well with the show’s narrative needs, embedding Best Medicine in a setting ripe for both scenic visuals and “fish-out-of-water” comedic setups.

What We Still Don’t Know

Even with this big casting reveal, several details remain under wraps:

• Character specifics: How will Spencer and Segarra fit into the community and Dr. Best’s life? Are they staff at the medical clinic, small-town residents, or local officials?
• Tone: Will Best Medicine lean more comedic or dramatic? The presence of Spencer (medical drama) and Segarra (comedic roles) suggests a hybrid, but creative execution is key.
• Premiere timing: With production slated for summer, industry pattern suggests a 2026 premiere, but Fox hasn’t committed to a date yet.

That said, the strategic casting of Spencer and Segarra signals ambition. Fox appears to be building the show with enough dramatic legitimacy (Spencer), comedic ease (Segarra), and established star power (Charles) for a well-rounded ensemble.

Trending

Best Medicine is shaping up as an intriguing addition to Fox’s lineup. The casting of Abigail Spencer and Josh Segarra brings both drama and comedy experience to the table. With summer production underway, the series aims to blend heartfelt storytelling with comedic charm, all centered around the relatable quirks of small-town life and a socially blunt medic returning home.

For now, the team behind Best Medicine has laid a solid foundation with Spencer and Segarra stepping into key roles. Their involvement adds both credibility and curiosity to the project.

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