Grey's Anatomy Season 21 cast and characters: Here’s who brought the ABC medical drama to life

Grey's Anatomy is one of the longest-running medical dramas, which continues its legacy by bringing in some fabulous characters every season.

Many characters left the show and got shuffled, leaving their echoes behind. In season 21, which debuted in 2024, the show's world expands to include more new doctors in Grey's Anatomy.

The core characters return in season 21, reprising their roles, while it has also featured some guest stars who carve out the narrative.

Keep reading for the full cast and character guide of who plays whom in Grey's Anatomy Season 21.

Here is the full cast and character guide about who plays whom in Grey's Anatomy Season 21

Ellen Pompeo as Meredith Grey

Meredith Grey has been the heart of the show. Therefore, her return remains undeniable. Though Ellen Pompeo returned for season 21, she wasn't a regular cast member. She appeared in intervals as the actress was trying to focus on her mental health and family this time.

In Grey's Anatomy, Meredith has been seen struggling with maintaining a proper work-life balance, and season 21 gives us relief that she achieves what she deserves after a long hustle. She and Nick Marsh resolve their conflict and finally start a new life, buying a home in Boston. This is how the show has dealt with her story, giving the actress a bit of release from the hospital's responsibility based in Seattle.

Chandra Wilson as Dr. Miranda Bailey

Miranda is one of the last remaining original cast members who hasn't left the show even after 20 seasons. She returned for season 21 and continues to be essential to the hospital's identity, keeping the moral and ethical compass right. She is someone other newer doctors look up to.

Miranda is an attending surgeon in the hospital and in season 21, she was seen shaping the intern whom she had helped throughout the exam. One more layer to be seen in Miranda's character in season 21 is because of Ben, her husband's return, and them again working together, which has a history of impacting their married life.

James Pickens Jr as Dr Richard Webber

James Pickens Jr plays Dr Richard Webber, who was introduced as a poised and calm character but soon takes up a leadership and mentor-like role in the hospital. However, with season 21, the character's fate seems uncertain as Webber is suffering from serious cognitive issues. This might lead to him taking a retire from hospital work.

Jason George as Dr Ben Warren

Ben is now back in Grey's Anatomy to complete his surgical residency, which will put him in proximity with Bailey. Ben and Bailey's married life has always suffered because of their profession when they end up working together, and yet again, season 21 poses them against one another, exploring more themes like power dynamics and work-life balance. Therefore, for them, season 21 is about dealing with this tornado and still being able to build a life together.

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Meanwhile, Catherine Fox remains a looming force within the hospital, ensuring that institutional power struggles and ethical dilemmas stay front and center.

So these were some main cast members of Grey's Anatomy, without whom season 21 is incomplete. They continue to invest their time into their characters, while the supporting cast includes the new interns joining the hospital. Now that Meredith has stepped back and Bailey is taking up the mentorship role, these young doctors bear the responsibility of the drama and adventure that is about to unfold.

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