Grey's Anatomy Season 22 Episode 4: Release date news, time, streaming details, cast, and more

Grey’s Anatomy Season 22 has been bringing forth some exciting narratives as the team at Grey Sloan Memorial Hospital continue to navigate through complex cases while dealing with their personal life dilemma. The upcoming episode of the hit drama series will see Jesse Williams reprise his celebrated role, Dr. Jackson Avery. Episode 4 titled ‘Goodbye Horses’ will air on ABC on Thursday, October 30, 2025, at 10 PM ET. The episode can be streamed the next day on Hulu.

In Grey's Anatomy Season 22 Episode 4, the interns at the hospital will be seen handling an unusual trauma case, while Meredith will get into a surprising partnership to treat a complicated breast reconstruction procedure. Jesse Williams returns to guest star in the episode as Jackson.

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Grey's Anatomy Season 22 Episode 4 release and streaming details

Grey's Anatomy Season 22 Episode 4 titled ‘Goodbye Horses’ will air on Thursday, October 30, 2025, at 10 PM ET/9 PM CT on ABC. The episode will be available to steam the following day on Hulu.

Hulu’s standard plan is available at $11.99/per month. The premium plan for the streaming service that comes with no ads is priced at $18.99/per month. Episodes of Grey's Anatomy Season 22 will be available on the streaming platform.

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Grey's Anatomy Season 22 Episode 4 Cast details

Here is a look at some of the cast members for Grey's Anatomy Season 22 Episode 4

Ellen Pompeo – Dr. Meredith Grey

Jesse Williams - Jackson Avery

Chandra Wilson – Dr. Miranda Bailey

James Pickens Jr. – Dr. Richard Webber

Kevin McKidd – Owen Hunt

Camilla Luddington – Dr. Jo Wilson

Jason George – Ben Warren

Kim Raver – Dr. Teddy Altman

Chris Carmack – Dr. Atticus Lincoln

Alexis Floyd – Simone Griffin

Harry Shum Jr. – Dr. Benson “Blue” Kwan

Adelaide Kane – Dr. Jules Millin

Niko Terho – Lucas Adams

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What to expect in Grey’s Anatomy Season 22 Episode 4?

In the previous episode of Grey’s Anatomy Season 22, we found the surgical team performing a high-risk lung transplant. Bailey was also seen handling the dispute between Lucas and Bryant like the true leader she is, as she dealt with a trauma patient. Meanwhile, Teddy finally confesses about her ongoing divorce to Jo, who encourages her to focus on her happiness above all and she does. And Blue seems to have started on the wrong foot with new plastics fellow Kavita Mohanty.

Grey’s Anatomy Season 22 Episode 4 titled ‘Goodbye Horses’ will see the interns encounter a bizarre case that will leave them scrambling for answers. On the other hand, Meredith has her work cut out for her as she is faced with a challenging breast reconstruction case. Link, who was undergoing treatment after being injured in the explosion at the hospital, is getting discharged.

However, the cherry on the cake for fans is the return of Jackson Avery to the hospital in Grey’s Anatomy Season 22. In the teaser, we find Jackson welcomed by the staff. That said, his role in the episode remains to be seen.

The logline for the Grey's Anatomy Season 22 episode as per Rotten Tomatoes states,

“The interns juggle a bizarre trauma, while a complex breast reconstruction forces Meredith into a tense partnership.”

Watch Grey’s Anatomy Season 22 Episode 4 on ABC at 10 PM ET on October 30, 2025. The episodes are also available to stream on Hulu.

ALSO READ: Grey's Anatomy Season 22 Episode 3 recap: High-risk surgery keeps the team on their toes

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