Nurse Jackie made its debut in 2009. The show was based in a New York emergency room. At its center was a dedicated nurse battling personal demons while looking after patients.
The seasoned ensemble cast brought nuance and authenticity to their roles. Every performer contributed to making the series memorable. The entire cast created a world that felt engaging and realistic.
Cast and characters of Nurse Jackie
Edie Falco as Jackie
Edie Falco played the Jackie Peyton, an emergency room nurse at the fictional All Saints' medical institution.
Jackie dealt with addiction to prescription painkillers in Nurse Jackie. Her character dealt with demanding work responsibilities alongside a troubled personal life. Falco brought a lot of nuance to the role.
She displayed Jackie as both flawed and caring. The actress won a Primetime Emmy Award for her outstanding performance in acting. She received six consecutive Emmy nominations for the role.
Falco had previously gained fame for her work on The Sopranos. Her portrayal of Jackie became another career defining performance.
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Eve Best as Dr. Eleanor O'Hara

Eve Best portrayed Dr. Eleanor O'Hara who is a British physician. Eleanor was Jackie's closest friend at the hospital. The character provided both personal understanding and professional support in Nurse Jackie. Best brought sophistication and warmth to the role.
Eleanor understands Jackie's issues better than most colleagues. Their friendship formed the emotional core of several storylines. The doctor often covered for Jackie's questionable choices. She balanced compassion with professional responsibilities.
Best's chemistry with Falco made their sequences particularly unforgettable. The relationship between these two women was left raw and meaningful.
Eve Best has also appeared on another popular show called The House of Dragons.
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Merritt Wever as Zoey Barkow

Merritt Wever played Zoey Barkow, a nursing student in Nurse Jackie. Zoey started as an inexperienced newcomer to All Saints' Hospital. She looked up to Jackie despite not knowing about her addiction.
The character brought energy and optimism to the show. Wever's acting earned her critical recognition. She won a Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series.
Zoey evolved from naive student to confident professional in Nurse Jackie. Her relationship with Jackie switched over time. The dynamic between student and mentor created compelling television moments.
Merritt Wever has appeared in other shows like New Girl, Tiny Beautiful Things and Godless.
Peter Facinelli as Dr. Fitch Cooper
Peter Facinelli played the role of Dr. Fitch Cooper. Cooper showed up as a capable and charming physician.
The character often provided comic relief in chaotic situations. Facinelli balanced genuine emotion and humor in Nurse Jackie. Cooper's interactions with other staff people added more depth.
He respected Jackie's nursing skills. Their professional relationship displayed mutual appreciation across medical roles. The doctor's character growth revealed layers beyond the initial impression.
Paul Schulze as Eddie Walzer
Paul Schulze portrayed the role of Eddie Walzer the hospital pharmacist. Eddie had an affair with Jackie at the start of the show. He also provided her with prescription drugs.
Their relationship was morally complicated. Eddie genuinely cared for Jackie despite their on and off dynamic. His presence highlighted Jackie's struggles with addiction and loyalty.
The family of Grace, Kevina and Fiona
Dominic Fumusa portrayed the role of Kevin Peyton, who is Jackie's husband. He owned a bar and tried to keep his family together. Kevin stayed unaware of Jackie's addiction and affairs for many seasons of Nurse Jackie.
Ruby Jerins played daughter Grace Peyton. Machenzie Aladjem portrayed the younger daughter Fiona Peyton. The family dynamics added emotional weight to Jackie's decisions.
Additional cast of Nurse Jackie:
- Bobby Cannavale as Miguel Cruz
- Adam Ferrara as Frank Verelli
- Anna Deavere Smith as Gloria Akalitus
- Morris Chestnut as Ike Prentiss
- Stephen Wallem as Thor Lundgren
- Betty Gilpin as Carrie Roman