Patrick Dempsey stars in the first trailer for Memory Of A Killer as an assassin with a deadly secret

Once a heart-melter as McDreamy in Grey's Anatomy, Patrick Dempsey is making a risky comeback to the broadcast TV screens with Memory Of A Killer, which has released its very first trailer. In the Fox crime drama, Dempsey stars as a hitman called Angelo Doyle who is experiencing a nightmare of a problem: he is gradually losing his memory. It is not a glitzy instance of Hollywood-style amnesia, but the heart-wrenching reality of early-onset Alzheimer's intertwined with a tense thriller.

The trailer for Memory Of A Killer promises gunfights, mounting paranoia, and emotional scenes as Angelo struggles not to mix his criminal existence in New York with family life. However, when his wits start to fail him, the danger is only increased.

Angelo’s world in the Memory Of A Killer trailer

The new Memory Of A Killer trailer does not take time to introduce us to Angelo, a murderer, who is both vicious and highly vulnerable at the same time. We find him with sniper rifles and battling in dark alleyways, and then all of a sudden, inexplicably going limpet-like in his confused and terrified state and attempting to conceal his fading memory to a doctor. The difference is so dramatic: one minute he is on a hit and the next he does not know what day it is, or who to believe.

The Memory Of A Killer trailer additionally gives some clues about his personal life. He has a daughter who is beginning to suspect something is wrong, and people around him who might be aware of things as well. It is like Mr. & Mrs. Smith vs. Memento, but with a lot more emotions.

Why this might be TV’s next must-watch

It is not about the guns or even the action itself that makes this first look of Memory Of A Killer so intense, rather it is about the internal stakes of the main character. Angelo is not only attempting to survive, but he is also trying to escape the reality about who he is, and that inner turmoil is as frightening as anything.

Angelo's character will be brought to the screens by Patrick Dempsey with a certain element of silent threat and heavy emotional quotient, shaping it as a complex role that has the potential to become a significant breakthrough in Dempsey’s career. The series will be a huge topic of conversation in the new year with a trailer that simultaneously blends fast-moving suspense and heart-rending, human moments.

Memory Of A Killer: release window and more

There is more good news in case the trailer has caught your attention already. Memory Of A Killer is set to officially debut on Fox on January 25, 2026, as one of Fox’s major shows for the new year. It will also be released on Hulu the next day, that is January 26, 2026. This is an opportune time to do so, and this type of dark and suspenseful thriller is ideal when it is cold outside or when you watch it as part of a weekly series that leaves you guessing what happens next.

Patrick Dempsey will not have the show just to himself. Another significant cast member is Michael Imperioli, who adds his usual intensity to the story as a Dutch crime boss. Odeya Rush will play Maria, Angelo's daughter, and Richard Harmon will star as hitman Joe. There is also an excellent supporting cast including names like Gina Torres, Peter Gadiot, and Daniel David Stewart, to make the situation even more interesting, hinting at the hidden motives, changing loyalties, and secrets about Angelo Doyle that are gradually waiting to be unraveled.

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