The Twisted Tale of Amanda Knox cast and character guide: Who plays whom in the Hulu biographical drama?

The Twisted Tale of Amanda Knox is Hulu's coming-of-age biographical drama that revisits one of the world's most hotly disputed trials over the last two decades. The eight-part series revisits the wrongful conviction and final acquittal of Amanda Knox, whose name was familiar in households around the globe in international news during the late 2000s.

The Twisted Tale of Amanda Knox will broadcast weekly through October 1, 2025, following its premiere on Disney+ and Hulu on August 20, 2025. It follows the 2007 killing of Meredith Kercher, the courthouse soap operas and media frenzy that ensued, and the existence of a college coed who was raised in Italy.

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The complete cast and characters of The Twisted Tale of Amanda Knox, and who plays who in the show, are listed below

Grace Van Patten as Amanda Knox

Grace Van Patten plays the main character, Amanda Knox, in the show. She has also previously worked on Nine Perfect Strangers and Tell Me Lies. Van Patten acts out Knox from when she is first in Italy until she is a grown woman fighting for justice. In The Twisted Tale of Amanda Knox, she plays the metamorphosis from a teen high school foreign exchange student to a young woman embroiled in a global controversy and the toll of wrongful imprisonment.

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Rebecca Wisocky as Cecilia

Rebecca Wisocky is the actress who takes the character of Cecilia, a repeat in the case's story of Knox. Wisocky is also known to have been part of Desperate Housewives, Devious Maids, and Ghosts. In The Twisted Tale of Amanda Knox, her character gives us a notion of the background of the general context in which Knox is introduced and the media hype, and how it affects individuals involved in the case.

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Anna Van Patten plays Deanna Knox

Anna Van Patten portrays the role of Deanna Knox, Amanda's younger sister. Deanna's performance as a character in The Twisted Tale of Amanda Knox highlights the psychological pressure that all the family members suffered through the lengthy legal ordeal. Deanna was also a very well-known face on the public scene as Amanda's supporter throughout the trials, and the series brushes against this sisterhood in their family dynamics.

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Sharon Horgan as Edda Mellas

Sharon Horgan plays Edda Mellas, the mother of Amanda Knox. Her experience with Catastrophe and Bad Sisters is applied to a level of depth that she brings to the mother of a daughter involved in legal issues and is under investigation. She is also a comforting presence and emotional support in The Twisted Tale of Amanda Knox.

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John Hoogenakker as Curt Knox

John Hoogenakker is Curt Knox, Amanda's father. Previously seen in projects like Dopesick and Tom Clancy's Jack Ryan, Hoogenakker brings Curt to the screen as a gentle giant trying to play catch-up in the maelstrom of a world case. In The Twisted Tale of Amanda Knox, he portrays the way the trial hadn't only changed Amanda but also her whole family.

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Giuseppe De Domenico portrays Raffaele Sollecito

It is Giuseppe De Domenico who takes on the role of Raffaele Sollecito, Amanda's then-boyfriend, when the murder was committed. Unjustly jailed, Sollecito's story also closely resembles Amanda's, and in The Twisted Tale of Amanda Knox, everyone will observe exactly how his life was irrevocably altered because of the trial.

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Francesco Acquaroli as Giuliano Mignini

Francesco Acquaroli is an Italian actor who stepped into the spotlight with his performances in The Red and the Black. Francesco Acquaroli acts as Giuliano Mignini in The Twisted Tale of Amanda Knox, Sollecito, and Knox's official investigator. Francesco Acquaroli had worked on the Netflix show Suburra: Blood on Rome.

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Roberta Mattei acts as Monica Napoleoni

Roberta Mattei portrays the character Monica Napoleoni, the detective who led the investigation. Her performance in The Twisted Tale of Amanda Knox does an adaptation of the investigation process, which had finalized the way the trial had been conducted. Roberta Mattei is an actress who has appeared in films such as Veloce come il vento.

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Rhianne Barreto played the character Meredith Kercher

Rhianne Barreto stars as Meredith Kercher, the roommate and murder victim of Amanda Knox. Barreto also starred as a supporting actor on Amazon's Hanna. Barreto's performance on The Twisted Tale of Amanda Knox is important to remind the audience about the sad loss and brings a fitting picture of the life of Kercher.

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Other supporting cast

Joe Lanza stars as Chris Mellas – Amanda's stepfather, her sponsor in the case.

Crosby Fitzgerald as Madison – A role familiar with Amanda Knox's peer group.

Journalists, detectives, and lawyers who fill out the scene of the case on screen are also familiar faces.

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Plot summary

The central topic of The Twisted Tale of Amanda Knox is the dramatized version of the murder in 2007 of British exchange student Meredith Kercher in Perugia, Italy. Her American roommate, Amanda Knox, was shortly thereafter the central subject of inquiry. The series follows the wrongful conviction of Knox, the media fiasco that had poisoned worldwide opinion against her, her four years in jail, and the ultimate acquittal.

The show isn't entirely about Knox, however, but about the prosecution of her family, Raffaele Sollecito, her boyfriend, being unjustly accused of the crime, and the prosecution of the case. The audience is also observing the later revelation of Rudy Guede as the actual killer, which changed the trial's course.

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Why this cast excels

Of interest in The Twisted Tale of Amanda Knox is the multinational cast of American and Italian actors. To have actors like Grace Van Patten, Sharon Horgan, and Giuseppe De Domenico gives a multicultural cast that befits the international context of the case. All characters, family members, the prosecutor, detective, or victim are involved in the dramatization.

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Its initial eight-episode series release on August 20, 2025, on Hulu and Disney+, The Twisted Tale of Amanda Knox promises fact-to-fact storytelling of the Amanda Knox story. Casting enables the audience to view not just Amanda, but also her friends and family and the legal authorities who defined her path through the courts.

With Amanda Knox's unjust conviction, media trial, four years in prison, and ultimate exoneration, the series attempts to give a complete dramatization of a case that is a touchy topic. Characters are what enable us to get the many sides of a story that was a ten-year world news headline.

Also read: "Way more complicated": Amanda Knox shares her feelings about the interrogation scene in The Twisted Tale of Amanda Knox