Alexis originally arrived in Port Charles in 1996 to defend Kevin Collins for stalking Felicia Jones. She then defended Monica Quartermaine in the sexual harassment case that Dr. Dorman brought against her. Alexis remained in Port Charles to look out for the man she was raised to believe was her cousin, Stefan Cassadine. Alexis perceived Katherine Bell and her relationship as a threat to Stefan and his family and she worked to convince Stefan that Katherine was his half-sister, Natasha, who had been believed to be dead. However, Stefan discovered her plan and wanted nothing more to do with her. To make matters worse, Alexis then found out that she was the real Natasha.
Helena had murdered Alexis' mother, and threatened Alexis with the same fate should she not do Helena's bidding. Helena forced her to defend Tony Jones for kidnapping, which cost Alexis her relationship with Ned Ashton as well as her job at ELQ. Alexis was desperate to get rid of Helena and she teamed up with Luke Spencer. Together they set a trap for Helena but Katherine stepped into the trap instead and was presumed deceased. Stefan was accused of Katherine's murder but Alexis defended him and revealed that she was his sister. She also mended her relationship with Ned and their romance resumed.
When Alexis learned that Nikolas was not the prince, she felt betrayed that Stefan had kept the truth from her for so long. With the Cassadine fortune up for grabs, Alexis decided to go after it with the help of Jasper "Jax" Jacks. But when she almost ended up dying in a plane crash that Helena caused, she decided that the risk was not worth it. She then decided to concentrate on building a life away from the Cassadines by focusing of her profession and her relationship with Ned.
When Chloe Morgan appeared in town, she immediately became friends with Alexis and Ned, as well as Jax. Chloe's new friends stepped in to help her when she was in danger of losing her company if she did not marry within the month. Alexis suggested that Ned and Chloe marry in Las Vegas and everyone agreed. However, Chloe's Aunt arrived and claimed that a Las Vegas wedding did not qualify. In order to cover up the real plan, Jax and Alexis got married instead. To make it appear that Ned and Chloe's impending marriage was real, Jax and Alexis needed to make it appear as though their marriage was also real. They even went so far as to move Alexis into Jax's penthouse. Jax and Alexis became good friends while married, as did Ned and Chloe. The four finally divorced when Chloe's Aunt Gertrude caught Chloe and Jax together. Alexis immediately, at Ned's request, moved the elegant promise ring he had given her from her right hand to her left, which made them officially engaged.
With Ned and Alexis happily and publicly together again, Ned decided to restart his music career as Eddie Maine. One night while on tour in Detroit, Ned returned to his hotel room with an interviewer and camera crew doing a story on "A Day in the Life of Eddie Maine." All was going well, that is until Ned opened the door to find Alexis waiting on the bed for him wearing nothing but a teddy and holding a rose in her teeth. Affectionately nicknamed "Eddie's Angel," Alexis could do nothing to escape the press, fan letters, Internet sites, and emails. Attempting to end the fiasco, Ned proposed to Alexis because he thought that if they were married, the press would leave them alone. Unfortunately, he was proved wrong when their private wedding in Belize was discovered.
Ned then decided that the best way to get rid of the press was to give them exactly what they wanted, a publicized wedding. After reluctantly agreeing, Alexis and wedding planner Elton arranged a big public wedding, complete with press. After many obstacles, they finally made it to the wedding day. As Nikolas escorted her down the aisle, Alexis began to have nightmares about becoming a Quartermaine wife, and fled.
When Ned's cousin, Emily Quartermaine became involved with Zander Smith, she arranged for Alexis to be Zander's lawyer, as he was in a lot of trouble with the law and mob boss, Joseph Sorel. Also, in exchange for his testimony against Sorel, Alexis' client, mob boss Sonny Corinthos, would give him protection in the event that Sorel tried to kill him. On the night that Zander was released from jail, Emily, Zander, Alexis, and Sonny were walking down the steps of the Port Charles Police Station, when two gunmen dresses as police officers opened fire on them. Sonny jumped in front of Alexis, and he was hit instead of her.
At the hospital, Ned was relieved to see that Alexis was not hurt, and although he had not completely forgiven her for leaving him at the altar, they agreed to work on their problems. That didn't last long, though, and they continually fought. Ned felt that Alexis was choosing her career over him, and Alexis was trying to deal with her fear of commitment and marriage. They decided that the best thing to do was to call it quits to their four-year relationship and go their separate ways. After breaking up with Ned, Alexis channeled all her energies into defending client Sonny Corinthos against his various enemies. They lived across the hall from each other, and their similarly dysfunctional childhoods, along with a tendency to shut people out, caused them to bond.
In summer 2001, Alexis began searching for her long-lost sister, Kristina. Right before Alexis' mother Kristin was murdered, she asked Alexis to go hide with baby Kristina. Alexis put the baby in the stables and then returned to the house, where Alexis found her mother dead. Helena had murdered Kristin by slitting her throat. When Alexis went back to the stable, Kristina was gone. With Jax's help, Alexis located her, and they had a joyful reunion, although Kristina soon spent her every waking moment nagging Alexis about her love life.
The main man in that love life was Sonny. Alexis found herself being increasingly goofy and shy in his presence, being hypnotized by his manner and looks, and slowly realized she had fallen in love with him. He played games with her, teasing and flirting, but he had feelings for her as well. Finally, in May 2002, they could no longer contain their emotions and had sex. Unfortunately, Carly saw them and ran out, then got into a car accident, which caused her death. Alexis and Sonny were guilt-ridden, and when Carly returned from the dead several days later--she had kept her status quiet for a period of time after recovering, but told no one about it--Sonny reunited with her.
Alexis stepped away from Sonny and his second chance with Carly. Then she realized she was pregnant with Sonny's baby. She planned to keep the pregnancy a secret while she contemplated her next move but Ned accidentally learned of her condition. Alexis told him that the baby was Sonny's. Carly also found out Alexis was pregnant and confronted her about it. Alexis couldn't deny she was pregnant, and Carly figured out that Sonny could be the baby's father since their one-night stand together happened a month or so before. Alexis told her eventually but Carly agreed not to tell him, since she feared that Sonny would want to be part of the baby's life and since she was not able to really conceive right then, it was a threat to her own happiness.
After Alexis resigned as Sonny's attorney, he learned she was pregnant but Ned stepped in and claimed that he was the father of the unborn child. Although Ned was involved in a relationship with Alexis' sister Kristina, they decided to continue the lie. Kristina was hurt by the news until she found a notepaper taken from Alexis' journal that said that Sonny was the baby's father. Kristina left to find Sonny at his warehouse and unknowingly walked into a bomb meant for Sonny. She was killed in the explosion.
Alexis blamed Sonny for her sister's death, as well as his mob rival Alcazar. She was grateful that Ned had the foresight to arrange for a false paternity test after Sonny wondered if he could be her child's father. Meanwhile, Alexis continued to try to bring Alcazar down for the death of her sister. When Alcazar was exonerated of all charges, Alexis was devastated and later confronted him when she saw him in the park. Alcazar refused to accept guilt for her sister's death and told her that it was her fault for sleeping with Ned and making her sister go to Sonny for answers. Alexis started to get strong contractions and asked for Alcazar's help. Alcazar refused to help her and left her in the park alone. Alexis couldn't find her cell phone so she could call for an ambulance.
Psychiatrist Cameron Lewis found her and took her to the hospital. She gave birth prematurely to a daughter whom she named Kristina. Her daughter spent weeks in the neonatal unit but eventually Alexis was allowed to take her home. Once Kristina's health was stable, Alexis reconsidered her decision to name Ned as her child's father after she caught him kissing a mobster's widow. However, she was forced to allow Ned to remain in Kristina's life after he threatened to reveal her true paternity.
As time passed, Alexis became more unspooled and she was arrested for Alcazar's murder. She claimed that she had Multiple Personality Disorder and that her alter "Kristina" was responsible for the murder. Cameron attested to her condition although he realized she was faking, but kept quiet because of his feelings for her. Alexis was declared not guilty by reason of mental defect, but paid a heavy price -- Ned was awarded custody and she had to face a long psychiatric treatment.
Alexis still ached to be close to Kristina. Ned was spending time with the unstable Skye, who hated Alexis and also desperately wanted a family of her own due to infertility. Alexis decided she had to keep an eye on her daughter's welfare. When the Quartermaine butler, Reginald, was injured, Alexis showed up in full drag, including beard, and claimed to be an experienced servant named Dobson. "Dobson" was hired and, over the next few months looked out for Kristina, sparred with Skye, tried to convince Ned to give Alexis a chance at parenthood, and bonded with Emily. Cameron once again found out about this ruse because Alexis was missing her critical court-appointed therapy sessions, and he once again covered for her because of his feelings for her. Finally, Skye colluded with Alexis' therapist--not Cameron--and D.A. Scott to expose Alexis during a big dinner party. They announced plans to arrest Cameron for his part in the cover-up.
Alexis couldn't let a man who had done so much for her take the fall. She took off her disguise and admitted that she had faked a mental disorder without Cameron's knowledge. Scott couldn't get to Alexis because of double jeopardy laws, and Ned blackmailed him into leaving Alexis and Cameron alone. Still, Alexis wanted custody of her daughter but a restraining order was taken out against her. Kristina was rushed to the hospital and Alexis convinced Bobbie to let her hold the child while Bobbie shut off an alarm. Skye caught her and had her arrested. Alexis felt more isolated than ever and reached out to Stefan to help get her daughter back.
Eventually Alexis gained custody of her daughter again and began focusing on both her career and her daughter. With little time left for romance, Alexis was extremely irritated when she first found herself the focus of Ric Lansing's attentions. They were forced to work together as opposing council on a trial. Ric, already aware that Sonny was truly Kristina's father, made it a point to seek Alexis out and seduce her. Ric learned quickly that suffocating Alexis with kisses was a quick and effective way of silencing her constant ranting.
It was also at this time that Alexis was confronted by Carly, who was looking at reconciling with her husband, Sonny. Carly wanted to tell Sonny that Kristina was his daughter so the couple could start over without any secrets, but Alexis begged Carly not to tell, and pleaded with her from one mother to another. Carly agreed to keep her secret, but had her reservations. Eventually the two became more than just enemies who enjoyed the occasional kiss, and a friendship formed.
It was that friendship that helped Alexis stay strong while her daughter faced leukemia. The only cure for Kristina was a bone marrow transplant with the likely matches--family members. It didn't take long for the doctor to discover that Ned was not Kristina's biological father, though all the Quartermaines were tested. She refused to admit to the doctor that Sonny was Kristina's father but broke down and told Ric, who did not admit that he already knew.
Ric was immediately tested, but was not a match. Even after a confrontation with Carly, Alexis refused to tell Sonny that he was Kristina's father because she believed that a life as Sonny's daughter was as dangerous as a battle with leukemia. Alexis continued to search for other possibilities while her daughter's situation grew grim. It became clear that Sonny had to learn the truth, but Ric had other plans first. Ric proposed to Alexis, in hopes that their marriage would give Alexis leverage when it came time for a custody battle with Sonny, which was clearly going to happen. But there was a catch--Ric refused to let the marriage be in name only; if they were going to get married, they had to truly try to make the relationship work. Alexis agreed.
At about the same time, Carly was admitting the truth to Sonny, even though she knew that her marriage would end with the confession. Sonny rushed to the hospital, where he confronted Alexis and learned of the impending marriage. Sonny was tested immediately and began making plans for Kristina to live with him after she left the hospital. With Ric's help, Alexis filed a restraining order to keep Sonny away from Kristina. In the meantime, all of Sonny's family was tested as possible donors. No one was a match and things looked worse for Kristina. However, Sonny's unborn daughter with Sam McCall could be the answer. The treatment involved harvesting the unborn child's stem cells, found in the umbilical cord. But Kristina didn't have time to wait for the child to be born, so Sonny approached Sam and asked that she consider a two-week early delivery. There was a ten percent risk to the baby, and Sam couldn't justify that risk and refused to help. While Sam understood that Kristina would die, she felt she had to protect her baby first.
When Alexis learned that Kristina's only hope had refused to help, she ran to the chapel, where she found Sam praying alone. Alexis pleaded with Sam at first, but Sam still refused until Alexis placed enough guilt on her until finally, in tears, Sam said she would do it. But just as Sam tried to tell Alexis she would do it, she collapsed in excruciating pain. The placenta had broken away from the wall, and Sam's baby would have to be delivered early. Ric comforted Alexis as she learned that Sam's baby had died, but then urged her to approach Sonny and ask for the lifesaving stem cells. Thinking of Kristina, Alexis worked up the nerve to ask the grieving father to save his other daughter, Kristina. After a heated discussion, Sonny agreed, and the transplant took place.
Kristina's health improved, and Alexis and Ric prepared to fight Sonny in court. Things went very badly for Alexis in court, but Sonny shocked her by agreeing to share custody. Alexis and Ric nearly split up after Alexis learned he had known Sonny was Kristina's father from the beginning, and she began to believe he was only using her to get to Sonny, but the two reconciled. Kristina, along with Sonny's other children Michael and Morgan, were kidnapped not long after, but Ric never wavered in his faith in Alexis, and convinced Sonny that Alexis had nothing to do with the kidnapping. Alexis also learned she was pregnant with Ric's baby, which left her out of the search for Kristina because she needed to rest. Morgan and Kristina were rescued but were devastated to learn of Michael's death.
Fortunately, Michael turned up alive but his presumed death and Kristina's kidnapping convinced Alexis that her daughter was better off without Sonny in her life, but when she tried to fight Sonny on the custody, Ric would not go along with her. Alexis fled to London with Kristina, only to faces charges courtesy of Sonny when she returned. She joined forces with John Durant to bring down Sonny, and was thrilled to overhear Michael confess to Jason that he knew he murdered A.J., as it gave her leverage. After Ric learned that Alexis was draining the Cassadine accounts to bring down Sonny, he washed his hands of her, and drove the wedge even further between them when he insisted that Sonny didn't murder A.J.
Alexis was shocked to learn that Ric had been so adamant in fighting for Sonny because he knew Michael was the real killer and wanted a chance to try again, but Ric couldn't trust that she was finally over her vendetta with Sonny, so they decided to divorce. Things hit a snag when their lawyers wouldn't help them divorce until after the baby was born, so Alexis began pushing Ric to cheat so they could get the divorce quicker. Their marriage took a turn for the better after Alexis experienced trauma in the hurricane and was barricaded at the Quartermaine mansion, with Ric in attendance. Both wanted to reconcile, but still couldn't trust their feelings. Alexis was shocked to learn at Lucky and Liz's wedding that Ric and Reese had a one-night stand while she and Ric were estranged, but in the train accident that followed, Ric and Alexis were able to put all their differences aside as they welcomed their new daughter, Molly, into the world, and decided to really make a go of their marriage.
Ric and Alexis were both taken ill with the encephalitis plague that hit Port Charles. Alexis received an early dosage of the serum, enabling her to be able to go home with the girls, but Ric remained ill. As Alexis worried that Ric wouldn't make it, she confessed a secret to him that she had never told -- when she was sixteen years old, she had given birth to a baby girl, on May 11, 1980--Mother's Day. Mikkos had taken her to a private clinic in Chatham, Maine, then forced her to give her daughter up for adoption. With Ric's help, Alexis decided to search for her long-lost daughter.
Alexis found out that Sam McCall was the daughter she gave up when she was 16. Sam and Alexis had a rocky relationship, and they couldn't agree on Sam's relations with hit man, Jason Morgan. In August of 2006, there was a city-wide blackout. After having a fight with both Ric and Sam, Alexis went home, only to find her husband and daughter having sex on her living room floor. In an attempt to keep Jason from seeing that, she made him take her to the hospital.
Alexis was diagnosed with lung cancer. Thinking she was going to die, she didn't confront Ric and Sam about what they had done, in order to keep her family together. Although Alexis initially refused chemo, she agreed to it in the end. After confronting Ric and Sam, she asked Ric for a divorce and alienated Sam. Ric quickly took Alexis to court in order to get custody of Molly. He even went as far as to arrest Alexis for smoking medicinal marijuana.
While at Wyndemere, Alexis met a charming man who she knew as James Brosnan. Little did she know that James Brosnan was an alias for James Craig, the man who blew up the Metro Court. However his true identity was Jerry Jacks, her ex brother-in-law. She became Jerry's lawyer as a favor to Jax.
Jerry pursued her relentlessly for over a year. She resisted a relationship with him, only indulging in the occasional kiss. In June of 2008, Anthony Zacharra threatened Kristina in an attempt to pressure District Attorney Alexis into releasing his son. Jerry promised Alexis that he would protect her and her daughters, and they made love. Many people, including Nikolas, Ric, Diane, Jax, Carly, and the PCPD, found out about it and expressed their disapproval. Alexis didn't care, however, and continued her affair with Jerry.
The mother-daughter relationship was still tenuous between Sam and Alexis when Sam flirted with Jerry. He told Alexis that Sam was pursuing him and Alexis asked Sam to stay away from Jerry. Alexis found Sam and Jerry kissing in Sam's hot tub. Sam claimed she was trying to find proof of Jerry's misdeeds by stealing his PDA. Alexis believed Jerry instead of her daughter and Sam was arrested when illegal drugs were found at her apartment. Jerry disappeared from Port Charles shortly after.
Mac Scorpio and Alexis worked together when a woman named Brianna Hughes was murdered. Brianna was Mayor Garrett Floyd's mistress and evidence was found that linked the mayor to the crime. When Mayor Floyd was arrested, he publically announced he was being framed by Alexis. Mayor Floyd revealed he had slept with Alexis and she wanted revenge against him because he would not leave his wife to be with her. Alexis claimed she had only slept with Mayor Floyd once, the night she found Sam and Ric together.
Kristina was most affected by having her mother in the spotlight and she doubted her mother had only slept with Mayor Floyd once. E-mails that were supposedly sent by Alexis to the Mayor were made public and they painted Alexis as a scorned woman. The mayor's wife, Andrea Floyd, continued to publically attack Alexis and the women had numerous arguments. Andrea suggested Alexis had been jealous of Brianna and was the murderer. Andrea planted evidence that supported her claim.
Alexis seemed more unstable when she confessed to being the driver in a hit-and-run. Kristina ran Claudia Zacchara off the road, and the accident killed Claudia's unborn child. Alexis confessed to protect Kristina and eventually the charges were dropped. Alexis was also cleared as a suspect in Brianna's murder when Robin Scorpio found evidence that proved Andrea Floyd was the killer.
Alexis was set-up on some dates with Mac Scorpio, courtesy of Robin, Maxie, Molly, Sam, Kristina, and Diane. The group arranged for Mac and Alexis to spend some holidays together and encouraged them to go on a few dates.
While Kristina encouraged Alexis to spend time with Mac, Alexis encouraged Kristina to spend more time with her boyfriend, Kiefer Bauer instead of her brother Michael. Kristina ran away with Michael to Mexico after Claudia's car accident. Alexis regretted her decision to support Kristina's relationship with Kiefer after she learned Kiefer had been abusing Kristina.
Kristina was severely beaten and taken to the hospital. Originally, Kristina claimed Ethan Lovett attacked her but Kristina refused to allow Alexis to press charges against him. Shortly after Kristina was released, Alexis found Kristina unconscious on the floor. Alexis raced Kristina to the hospital. Unbeknownst to her, Alexis hit Kiefer on the way to the hospital and he was killed. Kristina admitted Kiefer had abused her, not Ethan. Kristina said she covered for Kiefer at first because she feared retaliation from him.
Mac was very understanding when Alexis was charged with the hit and run accident that killed Kiefer. She was given community service which outraged Kiefer's parents. They decided to file a lawsuit against Alexis. Diane agreed to represent Alexis. Kiefer's father, Warren Bauer, continued to harass both Alexis and Kristina and threatened to force Kristina to testify at the trial. Alexis was grateful to Mac, Michael, and Ethan when the protected Kristina from Warren when he went on a shooting rampage in the hospital. He had verbally threatened Kristina and aimed a gun at her before he was shot and killed.
Alexis continued to be concerned with how Kristina dealt with the effects of the abusive relationship with Kiefer. Sonny and Alexis often disagreed on how to best help Kristina. Both Molly and Kristina were involved in a bus crash on their way to a ski trip. Kristina was treated for hypothermia, while initially Molly seemed fine. Molly suffered from post-traumatic stress disorder following the crash, and Alexis helped Molly receive treatment.
Sonny and Alexis disagreed again on how to parent Kristina after Kristina accompanied Ethan Lovett to the Dominican Republic. Molly accidently led Sonny and Alexis to believe Kristina planned to marry Ethan, which prompted Alexis and Sonny to fly to the Dominican Republic to bring her home. Kristina was actually assisting Ethan in obtaining a divorce from his wife Maya Ward. Although Alexis and Sonny did not agree on how to handle Kristina's crush on Ethan, they threw a joint party to celebrate Michael and Kristina's high school graduation.
Kristina continued to pursue Ethan but Alexis was more concerned with Sam's relationship with Jason after the two became engaged. Alexis initially discouraged her eldest daughter from marrying Sonny's mob enforcer but she set her concerns aside and wished Sam and Jason the best. She remained angry with Sonny though after he had tampered with Jax's plane which resulted in Jax's presumed death.
Alexis set her anger with Sonny aside briefly when Kristina passed out after experiencing ongoing bouts of dizziness and neck pain. Alexis was stunned to learn that Kristina required surgery to remove a bone fragment that was pressing on an artery. Molly hypothesized that Kristina's injury could have been sustained months before when Sonny caused Johnny Zacchara's car to explode while Kristina was in close proximity. The cause of the injury could not be pinpointed but Kristina recovered in time to join Alexis and the rest of the family at Sam and Jason's wedding reception.
At the wedding reception, Alexis saw Kristina speaking to Kate Howard about a career in the fashion industry. Alexis did not want Kristina to forgo college to work at Kate's magazine Crimson. Alexis joined forces with Sonny and convinced him that it would be best if Kristina left Port Charles and he arranged for Kristina to be accepted into Yale.
While Kristina moved on to Yale, Diane decided to pursue her writing full time and suggested that Alexis take over legal counsel for Sonny. Alexis refused until Sonny reminded her that she owed him and she was forced to become his attorney even though she still blamed him for Jax's death. Her anger eventually shifted to Carly when she learned that Jax was alive and that Carly had known for months yet had allowed everyone to grieve.
As Alexis was kept busy at work representing the Corinthos organization, she was also busy with her two daughters that remained in Port Charles. Sam revealed that she was pregnant but did not seem enthusiastic about it and was reluctant to tell her mother why. Meanwhile, Molly made a new friend named T.J. and together they hosted an underage drinking party at the lake house. Molly's friend took the blame for the party and Alexis forbade Molly from spending time with him.
The troubles Alexis had with her other daughters were placed in perspective with Kristina's unexpected return from Yale. Kristina arrived with a camera crew and announced that she had dropped out of college after she learned that her parents had used Sonny's leverage to gain her acceptance. Kristina threatened to cut all ties with her family if they did not agree to support her new venture, a reality show entitled "Mob Princess."
Although Alexis was not thrilled with Kristina's new project, her attention shifted to Sam after Molly revealed that Sam believed she was not pregnant with Jason's child, but with a child conceived by rape. Shortly after Alexis learned the details of her grandchild's conception she helped Sam deal with the loss of her child. Sam gave birth to a son in a motel room during a storm but the baby was presumed dead. Alexis rallied her daughters together around Sam as they held a funeral for the baby. Sam's struggles continued after the death of her child as she and Jason drifted farther apart and she decided to live with Alexis.
While Sam's relationship faltered Alexis discovered that Molly had a relationship with her own. She accidently happened upon Molly and her boyfriend T.J. and was furious to realize that Molly had disobeyed her instructions to stay away from him. Eventually the teens and T.J.'s guardian Shawn convinced her to allow Molly and T.J. to date as long as they adhered to specific ground rules. Alexis and Shawn bonded over a game of strip pool while the teens were on a date elsewhere.
After Alexis spent more time with Shawn, she started thinking about him romantically. Around the same time, she developed a dangerously high fever and was hospitalized. Alexis recovered from her mysterious illness and was flattered to learn that Shawn had remained close while she was ill and she agreed to go on a date with him. Their date was postponed when Jerry Jacks returned to town and poisoned the water supply with a deadly toxin. However, Alexis did not have to worry about effects of the toxin because her mysterious illness had actually been the result of an inoculation that Jerry had injected in to her so she would be spared.
Even though Alexis was safe, her loved ones, including Sam and Molly, had been exposed and she feared for their safety. She also worried about Shawn after Jerry knocked him out while he kidnapped her and tried to take her away from Port Charles. Shawn found Alexis and rescued her from Jerry.
Alexis was grateful that Kristina had been out of town during the crisis until she learned that Kristina had been in Las Vegas and had married Trey Mitchell, the producer of her Mob Princess reality show. Kristina explained that she had married Trey as a favor to his father and that they planned to annul the marriage. Alexis and Sonny believed that Trey had taken advantage of Kristina and their suspicions were confirmed after Trey's father was revealed to be an enemy from Sonny's past.
Alexis handled Kristina's annulment and then helped Sam navigate through her feelings for Jason. All of the Davis women were thrilled when Sam's son was revealed to be alive and she reunited with Jason. Sam's happiness was short-lived due to Jason's presumed death and Alexis tried to offer support to her eldest daughter but Sam pushed her away.
Instead, Alexis offered her support to Sonny as he dealt with the loss of Jason and the loss of his fiancée Kate to her alternate personality Connie. Alexis worked with Sonny to find a way to legally commit Connie/Kate for psychiatric treatment. She was dismayed to learn that when the legal system had failed, Shawn had helped Sonny take matters into his own hands. Alexis begged Shawn to stay away from Sonny's organization and admitted that she cared deeply for him. The feelings were mutual and they decided to take their relationship to an intimate level.
Alexis and Shawn professed their love for one another but Alexis was unable to deal with Shawn's increasing role within Sonny's organization. She forced him to choose between her and Sonny. Alexis remained resolved to her ultimatum even after Shawn elected to continue his work for Sonny and she ended their relationship. Although Alexis was heartbroken over the end of her liaison with Shawn, her focus turned to Sam and her grandchild Danny. Sam's son was diagnosed with leukemia and required a bone marrow transplant. While searching for donors, Sam wondered if her father could be located and questioned her mother. Alexis tearfully admitted that as a teenager, she had naively experimented one night with alcohol and an older boy whose name she did not know. Her pregnancy with Sam was the result of that night and she had no way to track down Sam's father.
Through hypnosis, Alexis remembered that the name of Sam's father was Julian but she never knew his last name. Around the same time, a man named Derek Wells arrived in Port Charles and was a bone marrow match for Danny. Throughout the donation process and Danny's recovery, Alexis and Derek shared a flirtation while Sam investigated the identity of her father and learned that his name was Julian Jerome. As Alexis and Sam digested the news that Sam's father had been part of the Jerome crime family, Derek Wells publically revealed that his name prior to entering the Witness Protection Program had been Julian Jerome.
Both Alexis and Sam were stunned by Julian's admission and angered by his betrayal. Sonny explained that Julian had to hide his identity in order to attack Sonny's organization. Sonny threatened him but Julian reminded everyone that Danny's life could depend on him if the cancer were to return. Sam and Alexis begged Julian to bank his bone marrow but he refused. Alexis verbally attacked Julian for putting Sam and Danny in the middle of a mob war but Julian silenced her with a kiss.
As Julian continued to encroach on Conrinthos territory, Sonny discovered that Julian took orders and received financial backing from an unknown partner. When Ric returned to Port Charles, Sonny asked Alexis to flirt with Julian to learn if Ric was behind the Jerome organization. Alexis agreed but quickly gave in to her feelings for Julian and they became lovers. She stood by Julian after he named Ric as the head of the Jerome organization and she supported Julian's decision to leave organized crime.
While Alexis whole-heartedly believed Julian's statement regarding Ric, her daughter Molly believed Ric's claim that he had been set up by Julian. Molly openly accused Julian of lying and she refused to reside with her mother as long as she remained involved with him. Both Alexis and Molly were shocked when they received news that Ric had been killed during his attempt to flee police custody. As Molly grieved for her father, she was involved in a car accident which claimed the life of her friend Rafe Kovich, While Alexis struggled to fix her relationship with Molly, Julian suggested that he and Alexis no longer be seen together in public but meet in secret instead. Alexis agreed, unaware of Julian's true motives.