The Twisted Tale of Amanda Knox Episode 6: Release date news, time, streaming details, cast and more

Hulu’s latest true-crime drama, The Twisted Tale of Amanda Knox, premiered on August 20, 2025, with Grace Van Patten taking on the lead role. Created by K.J. Steinberg, the series revisits the controversial case of Amanda Knox, the American college student who was wrongfully convicted of murdering her flatmate, Meredith Kercher. The show captures the chaos of the rushed investigation, the intense media frenzy, and the harsh public judgment that painted Knox as a killer before the truth emerged. At its core, it is a story of resilience, highlighting Knox’s relentless fight to clear her name and ultimately prove her innocence.

Episode 6 of The Twisted Tale of Amanda Knox, titled "Colpevole," is set to drop on September 17, 2025. This episode delves into the aftermath of Amanda's first trial. Due to the constant accusations, Amanda falls into depression, and instead of rotting in prison, she decides to make her prison term better. Amanda, now confident, has made up her mind not to repeat the mistakes she made during her first trial. Can she prove herself innocent of Meredith Kercher this time? To know more, watch The Twisted Tale of Amanda Knox Episode 6 on Hulu.

Continue reading to know more.

The Twisted Tale of Amanda Knox Episode 6: Release date, time, and streaming details

The Twisted Tale of Amanda Knox Episode 6 drops on Wednesday, September 17, 2025, on Hulu. The latest episode will be available to stream at 3 AM ET. The episode will be available simultaneously globally. Here's the streaming time details

New episodes drop every Wednesday on Hulu in the U.S. Globally, viewers can catch new episodes on Disney+. Hulu subscription plan starts from as low as $9.99/month. Students with a valid ID card can avail Hulu at a discounted rate of $1.99/month. You can also subscribe to Hulu via add-ons and bundle plans.

The Twisted Tale of Amanda Knox Episode 5: A quick recap

Episode 5 of The Twisted Tale of Amanda Knox, Mr. Nobody, dropped on September 10, 2025, on Hulu. In this episode, the focus shifts from Amanda Knox to her Italian boyfriend, Raffaele Sollecito, who was also wrongfully accused of Meredith's murder. Beyond the investigators’ relentless questioning of Raffaele and their manipulation of evidence, the series also offers a glimpse into his childhood. The episode unpacks how police pressure and manipulation turned his quiet life upside down. Every step of the investigations seems rigged, but Raffaele's childhood trauma, mostly due to his parents' separation and his mother's death, makes him remain loyal to Amanda until the end. Things take a turn when Amanda writes to him that they would be better off as friends. A rushed trial takes place with the twisted evidence, and both Amanda and Raffaele are sentenced to 26 and 25 years in prison, respectively.

What to expect from The Twisted Tale of Amanda Knox Episode 6?

Episode 6 of The Twisted Tale of Amanda Knox is set to chart Amanda's darkest chapter yet. Previously, we saw how Amanda was proven guilty and given a 26-year prison sentence. In this episode, we might see how she's forced to adapt to the prion life. As her appeals near, no evidence might spark a shift in her favor. Amanda, determined, prepares to fight back. The stage is set for a tense courtroom battle that could redefine her fate. Apart from Grace Van Patten, the episode will also feature Sharon Horgan, Giuseppe De Domencio, John Hoogenakker, and Francesco Acquaroli, to name a few.

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Also read: The Twisted Tale of Amanda Knox cast and character guide: Who plays whom in the Hulu biographical drama?

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