St. Denis Medical Season 2 is all set to premiere on NBC on Monday, November 3, 2025. The season brings back the doctors and nurses of the titular hospital, who do their best to treat the patients despite being underfunded.Meanwhile, they have to protect their own sanity and deal with some personal struggles, but they do it all with a smile. The hospital staff will have some new cases at hand in the sophomore season, and fans are now excited to know when the series returns.The first episode of St. Denis Medical Season 2 will air on NBC on Monday at 8 PM ET / PT. Here is all you need to know about the new chapter’s premiere.The release date and time of St. Denis Medical Season 2 Episode 1 View this post on Instagram Instagram PostNBC has confirmed the release date and time of St. Denis Medical Season 2 Episode 1 as November 3, 2025, 8 PM ET / PT. But that is not all. The network has a special treat for fans on the premiere, as the second episode of the season will also be aired on the same day.The first two episodes of Season 2 will be broadcast back-to-back on NBC on November 3, 2025, at 8 PM ET / PT. Following the premiere, the season will air one new episode every Monday.The episodes will become available to stream on Peacock the next day, i.e., on Tuesdays. To stream the show online, you need an active subscription to Peacock, which costs $10.99 per month with a Premium plan and $16.99 per month with a Premium Plus plan.What to expect from the St. Denis Medical Season 2 premiere?As always, the doctors and nurses will be handling a new case every episode in the second season. Meanwhile, their interpersonal relationships will be in the spotlight. In the first episode, titled Aloha, Everyone, Matt and Serena try to navigate their working relationship after Serena learns that Matt has feelings for her. Meanwhile, Alex is still not over her vacation mode, and Joyce faces a problem in the birthing center. The logline of the episode reads:“Alex tries to hold on to her peaceful vacation vibes; Joyce faces a design crisis in the birthing center; Matt and Serena reassess their working relationship.”In the second episode, Mama Bear Activated, chaos erupts at the hospital when Bruce gets attacked. While someone decides to help him cope, others are concerned about the security at the premises. The logline reads:“After Bruce is attacked at the hospital, Matt helps him deal with the aftermath; Alex motivates Joyce to amp up security, while Ron and Serena debate who is more qualified to defend themselves.”St. Denis Medical Season 2 brings back Wendi McLendon-Covey as Joyce, Mekki Leeper as Matt, Josh Lawson as Bruce, Kahyun Kim as Serena, Allison Tolman as Alex, Kaliko Kauahi as Val, and David Alan Grier as Ron. Several guest stars are also set to appear in the show, including Kristen Schaal, Lauren Weedman, Frankie Quiñones, Lauren Lapkus, Tim Baltz, Ariana Madix, and Jeremiah Brent.For more news and updates about St. Denis Medical Season 2, stay tuned to Soap Central.