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Get ready to witness chaos and drama unfolding in St. Denis Medical Season 2 as it brings back the small and struggling hospital in Oregon. This medical institution is best described as the "safety net," which means that the doctors never hesitate to treat people who don't have money.
But because of this, the hospital always has insufficient funds, staff, and is under pressure to run the institution. The NBC TV show focuses on the doctors who remain patient during this tough time and give their all to help people.
So, St. Denis Medical Season 2 is just a few days away, as it has been confirmed to be released on November 3, 2025. Those who have cut the cords can also enjoy the show by streaming it on Peacock.
The story in Season 1 began with the introduction of the main characters: Joyce (the executive director of the hospital), Alex (head nurse), Dr. Ron (emergency room physician), Dr. Bruce (arrogant surgeon) and others who complete the staff of this small hospital.
Find out everything about the new upcoming chapter below.
St. Denis Medical Season 2 release date and streaming details
St. Denis Medical Season 2 premieres on Monday, November 3, with two episodes back-to-back, and airs on NBC at 8/7c. The following day (Tuesday, November 4), episodes will be available to stream on Peacock. In addition, all of Season 1 is available to stream on Peacock if fans want to catch up or rewatch.
Peacock does not offer a free trial, so fans will have to pay for a subscription plan. The plans range from $10.99/month for Premium (with ads) and $16.99/month for Premium Plus (ad-free). Viewers can select a plan that suits them.
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St. Denis Medical Season 2 cast details
The beloved main cast from Season 1 will be back for the new season. Wendi McLendon-Covey returns as Joyce, the ambitious but slightly over-the-top executive director trying to keep the hospital afloat.
David Alan Grier reprises his role as Dr. Ron, the grumpy yet skilled emergency physician, Allison Tolman plays Alex, the caring and empathetic supervising nurse who often ends up being overworked, and Josh Lawson is back as Dr. Bruce, a confident trauma surgeon who occasionally lets his ego get the best of him.
Other cast members include Kahyun Kim as Serena, Mekki Leeper as Matt, and Kaliko Kauahi as Val. Interestingly, St. Denis Medical Season 2 will have several guest stars like Kristen Schaal, Frankie Quiñones, Lauren Weedman, Jeremiah Brown, Ariana Madix and Jonah Beckett.
St. Denis Medical Season 2 plot details
St. Denis Medical Season 2 will continue with the often chaotic and absurd world of St. Denis Medical. The staff still lacks resources, and will continue to treat patients with care. After receiving a generous private donation, Joyce will find herself taking on more than she can handle.
The team still faces staffing shortages, internal conflicts, and burnout. The trailer of Season 2 teases some fun surprises, including the arrival of a therapy horse and a scene where Dr. Bruce discovers ChatGPT. Matt continues to pine for Serena, hoping to get closer to her; Dr. Ron might become obsessed with investment schemes; and Joyce could take up playing the marimbas.
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