The granddaughter of society blueblood Amanda Barrington, Alison was ordered to volunteer at the hospital by her grandmother for breaking her curfew over and over again. Alison didn't mind the hospital but wished there weren't so many sick people there. Alison was armed with a smart mouth. That all changed when Alison put her safety on the line when she helped Jamal Woods hide his pregnant friend Val from thug Cedric. Alison got much more than she bargained for when Cedric caught her snooping around. Jamal found Alison near Cedric's corpse. Jamal took her to GH where Kevin realized Alison had no memory of the event. To protect Ali, Jamal said he had killed Cedric in self-defense. Scott agreed to represent him. The DA bought his story. A short time later, Jamal's bail was revoked when the authorities came to believe that he, not Cedric, was the mastermind behind the numbers operation. Jamal visited Alison at GH and stuck to the story that he killed Cedric. Alison realized Jamal was going on the run and convinced him to hide out at her family's cabin. Kevin continued to treat Alison, but Rachel intervened and Alison remembered that she had been the one to kill Cedric. With Kevin's help, Jamal sneaked into the hospital to see Alison and she told him that she remembered killing Cedric. Alison refused to stay away from Jamal. Jamal pushed Alison away, but admitted that he had made a deal with Amanda to stay away from her. Alison was furious. Jamal and Alison convinced newcomer Jack to pose as "Chandler" Alison's new boyfriend in an effort to fool Amanda. Amanda told Alison that she could continue seeing Jamal but that she would be disinherited. Alison chose Jamal over Amanda and her money. They made love for the first time and Jamal was startled when Alison said she was moving in. Alison then started job hunting and ended up working at the Recovery Room. Alison and Jamal, both wanting money to buy gifts, wound up working as Elves at Wyndhams.

When an old foe/partner in crime Travis showed up, Jamal was tempted to go back to a life of crime. Luckily, Alison came up with a plan of her own and convinced Jamal to open up a bike shop in Port Charles. Alison and Jamal happily celebrated the opening of their bike shop, but their happiness stopped when Jamal received a visit from his old biker gang. Alison decided to thrive on the bike shop business by opening a cafe alongside the bike shop, which Jamal wasn't thrilled about. Amanda tried to make peace between them and ended up having a heart attack while arguing with Alison. She and Alison repaired their relationship and Alison received a mysterious gift of $25,000. She opened the cafe with that money. Turns out the money was not from Amanda, but Zach's. Zach made sure Jamal was indebted to him through the money, forcing Jamal to do one last race, which Jamal did. Zach wasn't done with Jamal and forced Jamal to race once more. Alison threw away Jamal's bike keys, making Zach force Jack to race, which led to Jack's death. Livvie blamed Jack's death on Alison, but they soon mended fences.

Alison and Jamal's relationship became strained by the appearance of two new faces -- Jamal's old flame, Valerie and an angel named Rafe. Valerie sprung a surprise on Jamal -- he had fathered her daughter, Hope. Alison, meanwhile, was forced to deal with her attraction for another man. When Valerie lost touch with reality after her parental rights to her daughter were severed by her adoption, Valerie attempted suicide. Her attempt failed, but she did land herself a spot in the hospital's psychiatric ward. Valerie escaped and held Alison at gunpoint. Jamal arrived and tried to wrestle the gun away from Valerie, but the gun went off and fatally wounded Valerie. Jamal took Valerie's death hard and blamed his relationship with Alison for Valerie's death. Alison found comfort in the arms of the man who was always there for her -- Rafe. The two made love in haystack in a nearby barn. At the end of 'Secrets', Rafe was taken back to heaven. A devastated Alison started trudging on the railroad tracks, and got her foot stuck in the tracks, as a train headed straight for her. Luckily, just in time, Paige arrived and pushed Alison out of the way, saving her life. Alison started pushing her loved ones away and isolating herself in the barn. One day, Alison dreamed about Rafe, but when she woke up, the pink rose that Rafe had given her in her dream, appeared. Alison's great-great-great-grandmother, Rebecca Barrington (the black sheep of the Barrington family) stepped out of her portrait, and comforted a broken-hearted Alison. When Livvie, Jack, and Jamal found out, they started investigating Rebecca, and found out that she had been accused of being a witch and a murderer, and that she was hung for murder. They went to Alison with this information, but it was no use; Alison insisted that Rebecca was innocent. When Alison asked Rebecca about what she had been told, Rebecca answered that all she had done was make magic candles that made people feel better. Then, she had started to use them to play tricks on people. Rebecca also told Alison that the reason she was convicted of murder, was because everyone thought that she had killed a minister, when in fact, she had just helped him make it look like he was dead (upon his request). Rebecca taught Alison how to make the magic candles, Alison gave them to her friends. From her experience with Caleb, Livvie was afraid evil was seducing Alison, and that she was in danger. Livvie insisted that Alison forget about the candles and Rebecca, but Alison refused, so Livvie took Rebecca's things and burned them. Alison soon after opened a candle shop, The Pink Rose, and made more magic candles to sell. Livvie asked Kevin to help her convince Alison to close the candle shop, but it was to no avail. Kevin took some candles to have them tested for drugs, but before they could be tested, Livvie laced them with drugs, however Jack accidentally inhaled a drugged candle and it made him think there were bugs all over him, so he had to be admitted to the hospital. Jack figured out what Livvie had done and told her to tell the truth, but she maintained she hadn't touched the candles. One night, Kevin went to the candle shop to beg Alison to shut it down. A pitchfork fell on his arm and broke his watch, and when Alison went to the back for a minute, leaving Kevin all alone, Rebecca emerged from the painting, and lit a candle to make Kevin disappear. When Alison came back, Kevin was gone. The police arrived and found Kevin's broken watch and Alison's bloody apron. They got suspicious when Alison told them that Kevin had come to ask her to close down the shop. Alison was taken down to the station, and Livvie was furious, as she thought that her friend had murdered her father. When walking a bit from the barn, Livvie found Kevin's bloody shirt. She planted it in Alison's car, just in time for the cops to find it. Alison was then arrested for Kevin's murder. "NaNa" hires a NYC attorney Kate Reynolds to represent Alison in her murder trial. Ali attempts to tell Kate the truth, but hard as nails Kate will have no truck with vanishing psychiatrists, walking portraits, and magic candles. She decides to go with the idea to cast doubt upon the idea that Alison was the only one who would profit from Kevin's death, by attempting to cast Lucy Coe-Collins and Ian Thornhart as lovers trying to do away with an inconvenient spouse. Alison becomes so angry at Kate for this ploy, she fires her and confesses to Kevin's murder. In the interim, Jack has found an old camera in the trunks in the barn and has snapped some photographs on the old glass plates of both Alison and the barn. When he develops them after Alison's arrest he discovers they have captured Rebecca Barrington's image. He and Jamal go to Kate with the new information gradually winning her over to see things their way. The friends put on a historical play showing the entire story of Rebecca and the minister for the Judge and when he declares that Rebecca was no murderer, and at the clearing of her name, Rebecca is released from the Limbo to which she'd been exiled for 120 years and can proceed with her spiritual journey. However Kevin is still locked in limbo, now with no company at all. He cries out for Lucy, trying to keep her image in his mind, sketching her over and over again. One of these sketches mysteriously ends up on the patio of the "Lighthouse" for Lucy to discover. This is her signal from the "Universe" that Kevin is still alive and she uses all her considerable power and monies to attempt to free Ali, who was so convinced that the play would also free Kevin, collapses from a leaking brain aneurysm. She is rushed to GH, where no one is sure she will recover. Rafe, who has begged and threatened 'Ed' his heavenly boss to allow him to return to earth to help Ali, has sold his soul to James, Caleb's old manservant for a chance to return to earth. However, James returns him to earth with no memory of why he wanted to return, or any memories of any of the peoples important to his life, or his death or subsequent 'employment' as a guardian angel. He is found by Livvie who uses his amnesia as additional ammunition to destroy her 'enemy' Alison. When he wakes in the woods near the barn, he finds the candle Rebecca used to send Kevin to Limbo, and puts it in his backpack. Rebecca had told Alison the only way to restore Kevin to the world was to relight that candle, and an extensive search went underway to find it. Livvie tricks Rafe into believing he had returned to "PC" for her, that they were star-crossed lovers, and even tricks him into marrying her in the barn. Rafe always found peace in the chapel in the hospital, and one day, his nerves frayed from his inability to remember his past, he wanders into the hospital with the intention of visiting the chapel. Somehow he finds himself in Alison's room, and with vague memories of her swirling in his head, he kisses her, causing her to reawaken. He is horrified by his action, especially as a newly married man, and retreats to the chapel. He leaves the candle in the chapel, and we see a hand light the candle. Kevin is returned to Lucy, and we later learn Rafe himself lit the candle. Kevin's return clears Alison's name to the authorities, but Livvie's hate remains unabated.

Alison found herself at loose ends upon her release from the "PC" lockup, and Jamal and Jack came to her rescue. Jack jokingly took photos of her 'modeling' atop one of Jamal's bikes, and sent them into a motorcycle magazine publisher who immediately wanted to hire both Jack and 'his model'. Port Charles, meanwhile was mesmerized by the advent of a mysterious hooded apparition who surfaced to save women who found themselves in threatening situations.

After Alison's awakening, Rafe is continually drawn to her, and feels a strong connection to her, but he vows to stay true to his wife...especially when Livvie tells him that she is pregnant with his child. Though Alison had been fighting for Rafe to remember their love, including setting up meetings and events to jog his memory, she decided to back off when she realizes that her nemesis is pregnant with her true love's child. But little did she know that Livvie had actually made a deal with Frank Scanlon to get her pregnant so she can keep Rafe, whom she claimed to have really fallen in love with. Livvie had discovered that Frank was really the hooded man who had been saving women in trouble all over town, and offered her silence in return for a baby.

Alison was devastated, and tried to move on, kissing friend Jack one night while drunk. Ex Jamal also tried to help her by pretending to be her boyfriend in front of Rafe one night (it backfired). Though Ali and Lucy found proof that Rafe was not the baby's father (Lucy had a DNA test performed when Livvie was hospitalized), Alison had decided not to tell Rafe, as she wanted him to come to her of his own free will, and she did not want to take away the baby that he was already beginning to love. As Frank and Livvie each grew more out of control, Livvie told Frank (as the Avatar) to kill Alison so she would no longer be an obstacle to Livvie. Frank couldn't bring himself to do it, however, and instead let Ali go, so long as she promised to stay away from Port Charles. She started off, but got her leg stuck in a hunting trap. Rafe, fearing that the Avatar had gone after her (as it had done before to get to Rafe, since it knew that Alison was the way to hurt him), goes to look for Alison when he is struck by an image of her laying in the woods in pain. He follows the image, and finds the spot where Alison was, but no Ali. He realizes that the barn that Alison loves is nearby, and goes there, but is disappointed not to find her there. Rafe looks at the beam where he had once carved his and Alison's names (Livvie had shaved it clean), and wonders aloud why it took him so long to figure everything out. Taking out his pocket knife, he re-carves their names and that's how Alison finds him. Rafe looks at her and tells her he loves her. Though he still doesn't remember the past, he says it doesn't matter and they kiss. As they are kissing, all of Rafe's memories come rushing back to him. The couple reaffirms their love, and as Alison tells him he may "kiss his bride" (as when they married themselves in the barn), an angry Livvie shoots Rafe in the back. Rafe "dies" and gets called back up to heaven, while Alison confronts Livvie. Happy that she at least got to tell Rafe she loved him, Alison decided to leave town to get a fresh start. But as her train is pulling away, Rafe appears and starts running after it! Ali sees him, and running to the back of the train, she helps Rafe aboard. The two have a wonderful romantic reunion on the train.

Alison and Rafe, reunited, engaged and living at Lucy's old house, plan to marry on Christmas. The couple is happy, but a damper is soon put on their newfound joy when Alison finds out that her father, Malcolm, has died under mysterious circumstances. Soon, her errant mother Elizabeth returns home, and the reunion is not a happy one as Ali slaps her mother and berates her for all the years that she left her daughter alone while she traveled and lived the high life. There are more surprises in store for the Barrington women as Malcolm's will reveals not only that he cut Elizabeth out of his will entirely, but also that Ali has an illegitimate half-sibling who is to share in the family fortune! Elizabeth offers to help Alison find her brother or sister... if she gives her mother her new fortune.

Meanwhile, a band called The Stephen Clay Experience has become all the rage in Port Charles. Their song, "Naked Eyes" is played everywhere, and people all over are practically mesmerized. All except Lucy and Rafe, who are highly irritated by it.

Elizabeth, still smarting from the years of cheating she endured from Malcolm, only to be cut off, meets a handsome stranger, the mysterious Stephen Clay himself, who turns out to be a dead ringer for Caleb! Rafe also later comes face to face with the man, who denies ever hearing of a man named Caleb Morley. Ignoring everyone's warnings, Elizabeth continues to date him.

When Alison and Elizabeth get a lead on Ali's sibling, Stephen lets them use his jet to fly to Canada to meet with the women. On the way there, the plane runs into bad weather and crashes on an island. Alison is badly injured, and an emotional Elizabeth pleads for her daughter not to die, as they've just found each other again. She wants to make up for all the time they've lost, and all the pain she has caused, and is starting right that second. Stephen in the meantime tends to Ali's wounds, and basically saves her life. At one point, Alison looks up and whispers that she and Rafe were wrong: he couldn't be Caleb, because Caleb would never help her the way he has. She apologizes, and promises that everything will be different when they get back home. When the three are rescued (the pilot died), Alison tells Rafe what she has decided, and though he argues with her, he eventually promises to keep an open mind.

As Alison lay in her hospital room having this conversation with Rafe, we see Elizabeth at Stephen's hotel room telling him that she can't be with him anymore because it's time for her to put her daughter first. "I can't let you do that," he replies as his eyes glow red, his fangs show and Caleb bites her!

Interestingly enough, after Elizabeth becomes a vampire, she and Alison become closer, and together work on finding Alison's sibling (Elizabeth having torn up their contract for Alison's money). Elizabeth gives Ali some old love letters that belonged to her father, and a picture of the woman he wrote them to. One of the letters revealed that she bore Malcolm's baby!

Soon, Rafe and Ali's big day has arrived. Before the bride gets ready, Rafe gives her a present: a locket that belonged to his mother. He wants Ali to have it. She wears it on her wrist going down the aisle, but halfway down it gets caught on her wedding dress. It opens... and reveals a picture of her father's mistress; the one who bore him an illegitimate child. The picture, Rafe later confirms, is of his mother.

Needless to say, the wedding was called off, though there was another one that took place that day: that of Stephen/Caleb and Elizabeth.

Rafe tries to convince Alison that they cannot be brother and sister. She wants to believe him, but says that until they find definite proof, she can't marry him. Or make love to him, kiss him or live with him. He reluctantly accepts this, then fills her in on her mother's new status as a bloodsucker.

Alison decides to journey to her father's yacht to look for clues on her sibling. Elizabeth decides to tag along, as it was the last place she saw Malcolm and feels it might put some demos to rest for her. Stephen offers them the use of his plane again, though he sends his henchman Joshua along when at the last minute he decides to stay in Port Charles. Rafe sneaks along, as he has been wondering if this whole Sibling Situation hasn't been a plan of Caleb's to keep him and his love apart. While on the yacht, he overhears a policeman tell Joshua that, as requested, the boat had been thoroughly cleaned before the Barrington women arrived. Though he questions the yacht's caretaker, believing that Caleb and Joshua may have arranged for Malcolm's murder, the man is too afraid to talk. Later at the hotel, Joshua "worries" that Alison seems to want to stay in her room and not come out. After Elizabeth admits that Alison is there to find proof that she and Rafe are not brother and sister, Joshua drugs her drink. Ali walks in to see her mother on the floor, and she argues with Joshua. As he is leering over her in a threatening way, Elizabeth comes to, tears Joshua off of her daughter and sinks her teeth into him.

Luckily for Elizabeth (as Caleb warned her she was never to kill), Joshua isn't really dead, merely a vampire. But it is unlucky for the rest of the town, as Joshua becomes hungry for power, and is done with being in Caleb's shadow and doing his dirty work (including helping to set up Rafe and Alison to think they are related).

Rafe and Lucy come up with a plan to rid Port Charles of the vampires: there is a hot spring that runs underneath a building in PC. It is a healing spring. It's water (which is what Caleb, Elizabeth and the vampire members of the Stephen Clay Experience drink to curb their vampire symptoms) will transform any vampire who had drank blood back in to a normal person (as evidenced when Elizabeth jumped in and was healed). Rafe and Lucy plan to lure all the vamps to the hot spring and toss them in. Unfortunately, Joshua gets wind of their plans, and rigs explosives to blow up the underground spring with everyone inside it. With no Caleb around, Joshua will be the new king of the vampires!

Joshua's plans don't go as well as he imagined, as the former vampires and the slayers are not killed, but merely injured. He also did not count on the fact that Caleb had made Livvie into a vampire. But Joshua forges ahead with his plans, including one to make Alison his Queen. To bring down the new head Vampire, who has been making vampire soldiers of many of the townspeople, an interesting alliance of Livvie, Alison, Caleb and Rafe has formed. To stop Joshua from going after her, Alison faked her death. However, Joshua soon learns of the ruse and again takes Alison away to the mansion that Joshua has turned into his new headquarters. It is soon learned that some of the people who have become Joshua's latest victims include Frank Scanlon, Victor Collins, Jamal Woods and Alison's own grandmother -- Amanda Barrington! When Rafe rushes to Joshua's mansion to rescue Alison once again, Rafe is quickly overpowered by Joshua's guards. Alison tells Joshua that she will agree to marry him if he will let Rafe live. Rafe is released but anguished because he had to leave Alison behind in the clutches of a monster like Joshua. Caleb and Livvie learn that Joshua tricked Livvie into drinking a toast that included a potion which turned Livvie's fangs into poison. Livvie is afraid that IF she bites Caleb in an effort to restore Caleb's lost vampire powers, she will kill Caleb instead. Caleb tells Rafe that he will help Rafe rescue Alison if Rafe will help Caleb find the antidote for Livvie's poisoned fangs and recover the Morley Family Heirloom Power Ring, which Joshua had stolen from Livvie. Rafe finally admits that he has already discovered the antidote for Livvie's poisoned fangs. After Livvie takes the antidote, she bites Caleb and restores Caleb's magical powers. Rafe agrees to Caleb's plan and, with Caleb helping to distract Joshua, Rafe and Caleb show up in Joshua's mansion just before Joshua can make Alison his bride. As Caleb, Rafe and Joshua struggle, Joshua suddenly disappears in a puff of smoke, but Caleb discovers that the Morley Family Heirloom Power Ring is missing!

After Joshua disappears, Joshua's hapless victims learn that, because Joshua was not "of the pure blood," none of Joshua's victims can return to their former, mortal lives. Because Elizabeth, and band members Caz and Reese took a dip in the healing pool before it was destroyed, they return to their mortal lives. But Ian, Jamal, Frank, Victor and many, many others discover that they are cursed to remain vampires forever! The Morley Family's mystical ring falls into the possession of Jamal, Jack, and Christina. As Caleb continues to search for his mystical ring, Rafe becomes obsessed with trying to prevent Caleb from recovering the ring. Alison and Rafe begin to live in the loft above Rafe's gym and the couple begins to make plans again to be married. However, Rafe and Alison begin to have many arguments about Rafe's obsession with discovering Caleb's missing ring before Caleb finds it. It is revealed that the mystical ring has the power to grant any wish of whomever holds the ring ~ but the wish often backfires on the person making the wish. While Jamal has the ring, Jamal wishes for Livvie and Alison to trade places for a day and Alison begins to act tough like Livvie and Livvie shocks Caleb when she turns into a happy homemaker, like Alison! Alison's mother, Elizabeth Barrington, brags that she knows an important fashion designer, who is coming to Port Charles to design a special line of sportswear for the opening of Alison and Rafe's gym. However, when the fashion designer does not show, Elizabeth presses Dr. Chris Ramsey into impersonating the fashion designer. Elizabeth actually creates the 'designer' clothes for the fashion show, but does not let Alison know about her deception. During this time period, Alison's mother, Elizabeth, becomes romantically involved with Chris Ramsey. When Rafe and Alison hold the grand opening for their gym, Caleb sings a song guaranteed to bring the ring back to him. Baby Christina, who has the ring at the time, heads toward the stage, but a light fixture suddenly falls and hits Kevin Collins, which puts Kevin in a coma and injures Kevin's back, so that Kevin finds himself wheelchair bound. The light fixture did NOT fall accidentally ~ but, rather, the fixture fell because it was part of another attempt by Livvie to get rid of Alison forever. Although the ring is momentarily lost in the hubbub following Kevin's accident, Caleb eventually finds the missing ring. Rafe suspects that Caleb has recovered the ring and decides that it will be necessary for Rafe to travel to Hades to learn the secret of making the ring Rafe's possession. Rafe finds a book of ancient rituals and chants when Rafe breaks into Caleb's apartment in the hope of finding the ring. Rafe decides to use a chant he discovers in the book to make a trip to Hades. Alison is horrified when Rafe disappears in front of her very eyes. Alison goes to Caleb and, confessing that she KNOWS that Caleb has recovered his mystical ring, Alison begs Caleb to use the power of his ring to wish Rafe out of Hades and back to the mortal world. But, in the meantime, Livvie has stolen Caleb's ring and exchanged it for a fake. Caleb is actually aware of Livvie's deception but decides to give Livvie time to return the ring to him on her own. Hoping to make Caleb hers forever, Livvie wishes for Caleb to enjoy a night of grand passion and to be able to have a child of his own. (During Tainted Love, it had been explained that vampires can not produce children of their own and that was the reason why Caleb spent so much time trying to steal Eve's baby -- Daniel!). At the same time, Caleb bluntly informs Alison that he refuses to use the magic of the ring to help Rafe return to the mortal world. A devastated Alison immediately goes to the barn which was once so important to her and Rafe. While Alison is at the barn, Caleb suddenly shows up and tries to reassure Alison that Rafe will be able to take care of himself in the Netherworld. However, Caleb and Alison are alone together at the very moment that Livvie makes the wish that Caleb will enjoy a night of passion. Alison and Caleb suddenly find themselves hitting the hay together in the barn. Later, Rafe is suddenly released from Hades but is surprised that he can't find Alison at home. Rafe goes looking for Alison. Meanwhile, a guilt-ridden Alison leaves the barn. After Alison leaves, Caleb reveals that Alison was the only one who was under the spell of the ring ~ that Caleb was NEVER under the ring's spell! When Alison and Rafe finally find each other, Rafe promises that he is prepared to give up his obsession for obtaining permanent possession of The Morley Family Heirloom Power Ring and devote his life to being happy with Alison. Rafe then suggests that they be married at the barn where they made their first vows to each other. Rafe is mystified when Alison becomes very upset by his suggestion. Later, Rafe decides that what is bothering Alison is that many unhappy events ALSO took place at the barn. Rafe had, after all, also married Livvie at the barn during the time that Rafe could not remember who he was. It was also at the barn that Livvie shot Rafe in the back and Alison believed that Rafe was gone forever again. Alison tries to confess to Rafe about her night with Caleb, but just can NOT seem to get the words out. Later, at the gym, Alison is suddenly given a gift by a grateful gym patron. The gym patron hands Alison a reservation for a pre-paid weekend at a luxury Bed and Breakfast in the country. After Alison accepts the gift and begins trying to persuade Rafe to go to the Luxury Resort for their wedding, it is revealed that the grateful patron was really Caleb in disguise. When Alison calls to make arrangements for their wedding at the Resort, it is revealed that the Resort owner is a woman who is a fellow vampire-friend of Caleb's! As Rafe and Alison make their plans to be married at the resort, Caleb also convinces Livvie that THEY should be married at the SAME resort ~ AND at the SAME time! Later, after Rafe and Alison arrive at the resort, Caleb and Livvie arrive at the SAME resort. Livvie is not aware that Rafe and Alison are at the same Bed And Breakfast, but Caleb is WELL aware that Rafe and Alison are at the resort. Caleb even spies on Rafe and Alison as they get ready for their wedding! When it comes time for Rafe and Alison to be married, Rafe surprises Alison by suddenly producing their friends and family to attend the wedding. At the same time, Caleb and Livvie exchange vows in another suite of the resort. But, after Caleb and Livvie have exchanged vows, Caleb informs Livvie that he spent his night of passion with Alison -- and that Alison MIGHT be carrying Caleb's child at that very moment -- all because of Livvie's wish! While Rafe and Alison celebrate their wedding with friends and family, the newlyweds remain blissfully unaware of Caleb's revelation. But Livvie is devastated by the news!