Bobbie returned to childhood residence of Port Charles as a prostitute-turned-nurse and the secret that she had given a child up for adoption. She wanted desperately to marry Scotty Baldwin but although he visited her bed from time to time, he was in love with Laura Webber. So Bobbie got her brother to come to town as part of a plan to break up Scotty and Laura. When the plan didn't work, Bobbie pretended to be pregnant with Scotty's child, but Scotty ended up marrying Laura. Bobbie next fell in love with Roy DiLucca, a mobster and Luke's partner in the disco, who treated Bobbie like a queen and planned to marry her. He died in her arms after being shot while fleeing from his attempted assassination of Senator Mitch Williams. She then fell in love with Dr. Noah Drake and even went as far as to pretend to be blind in order to keep him. Noah made it clear he did not want to make a commitment. In 1983 she married financier D.L. Brock. Once they were married he became extremely abusive and he was ultimately murdered. She was initially charged with his murder but her attorney Jake Meyer proved that his daughter Terri killed him.

In 1986, Bobbie married Jake Meyer, who had a one-night stand with Lucy Coe. When Lucy became pregnant, Jake and Bobbie worked out a deal with her to raise Lucy's child as their own, but Lucy miscarried the baby. Around this time, a DVX agent who had taken the hospital cafeteria hostage scratched Bobbie with a deadly syringe. An antidote was found, but Bobbie was paralyzed. Bobbie's recovery was helped along by an optimistic and boisterous paraplegic, Martha McKee. Martha, who was suffering from pneumonia, had to move to Colorado after taking a turn for the worse, and Bobbie agreed to raise her kids, 10-year old Skeeter and teenage Melissa. Melissa rebelled, began hanging out with a bad crowd, injured Ruby when she and a friend robbed Kelly's, and fled to Miami with the friend. They fell prey to a pimp who forced them into prostitution. When the spurned boyfriend of Melissa told Bobbie, she flew down to Miami without telling Jake. Posing as a call girl, she planned to alert the cops to the pimp's illegal activities before she had to sleep with him. The police did arrive, arresting him-and Bobbie too! The recently returned Scotty Baldwin bailed her out, but her arrest made headlines in Port Charles; Melissa and Skeeter were taken away from her, and she and Jake weren't allowed to adopt.

Jake left town to help flood victims in Paraguay, partially due to being sick of her need for children. He tried to explain himself through the mail, but Scotty destroyed the letter and put doubts in Bobbie's mind because he wanted Bobbie for himself. After seeing a photo of Jake with his arm around a woman, she divorced Jake; and four months passed before she realized Scott's bad ways and dumped him. Bobbie then met a sophisticated, rich, handsome man, Gregory Howard, in a bar. Unfortunately, he was (unhappily) married. After weeks of talk and flirting, she finally agreed to go on a weekend with him, but a political party drafted him to run for the state assembly. Bobbie was left brokenhearted yet again as she realized his new political career and an affair wouldn't mix.

In 1989 she married her good friend and father of her namesake B.J., Dr. Tony Jones. In 1991, Bobbie treated a patient who bore an amazing resemblance to Luke Spencer. He was her cousin, Bill Eckert; the Eckerts and the Spencers had been strangers for years due to bad blood. Bobbie desperately wanted a baby and in fact purchased one from the black market. Unbeknownst to her the baby was Cheryl Stansbury's baby. Bobbie tried to keep the truth a secret, but the truth came out (putting a strain on her marriage), and she had to give the baby back to Cheryl. When Cheryl died, Bobbie became embroiled in a custody suit for the baby (Lucas) with Tiffany Donely, Cheryl's sister. The court awarded Bobbie custody of Lucas in 1992. Also in 1992, Bobbie began writing letters to ex-convict and cop killer Joseph Atkins after being impressed by his book, Violence Tamed. He wrote back, asking her to help him get parole. Tony went berserk when Atkins began calling Bobbie at home. Bobbie realized she couldn't support Atkins. When she cut off contact, he told her she'd be sorry. Months later, he broke into the Brownstone, holding her and Tony hostage and trying to rape her before finally being caught by the police.

In 1994, while spying for Luke, she began a flirtation with the evil Damian Smith, in fact Tony caught them in the stairwell of General Hospital embracing the day that B.J. was involved in a school bus accident and was killed. Although devastated by B.J.'s death, Bobbie was somewhat comforted by the fact that B.J.'s heart had gone to Felicia's daughter Maxie. Bobbie consummated her romance with Damian after Tony threw her out, but when she learned he had only seduced her as part of a bet with Lucy, she left him to die in the catacombs. They separated and after counseling eventually found their way back to each other, but Tony was emotionally spent, so things were never quite the same with them. Bobbie and Tony befriended a young woman that came to Port Charles, Carly Roberts, not knowing that she was really the baby that Bobbie had given up for adoption. On the day of her wedding anniversary to Tony, Bobbie found Tony and Carly in bed together and that was finally the end of their marriage. She then immediately turned to and married Stefan Cassadine. Eventually she realized that all the things her brother Luke and everyone else had been telling her about how horrible a man Stefan was, were true and agreed to help Luke expose him. She drugged a glass of wine he was drinking and thinking he had finished it, removed a medallion from around his neck that was the key they needed to open up a box he had. Stefan had not drunk the wine and therefore caught her and threw her out. She went to Puerto Rico and obtained a divorce.

Shortly thereafter, Bobbie learned that Carly, who was now engaged to Tony and carrying his baby, was really the daughter she had given up so long ago. Carly had a lot of anger toward Bobbie for leaving her, but the two were able to rebuild their relationship. The birth of Carly's son and Bobbie's first grandchild, Michael, helped a lot. When Bobbie found out Luke had known for a few years, and had lied to her that her baby had died, she coldly berated him, promising to never forgive what he had done. However, a Spencer is a Spencer, and she did. Bobbie was aggressively wooed by Jerry Jacks and fell in love with him. The height of her embarrassment was when their sexual exploits in the GH board room were accidentally filmed and shown at the Nurses Ball. She was devastated when her wedding to Jerry was thwarted by his arrest by FBI agents. Jerry jumped bail and left town after their tearful good-bye. Just before Jerry's arrest, Bobbie was stunned to find her old flame, Roy DiLucca, supposedly dead, was alive, well and in town. Her feelings about Roy were jumbled, but after Jerry left town, Roy and Bobbie renewed their love. Bobbie learned Roy was a federal agent, responsible for busting Jerry, but managed to forgive him before he was taken back to jail. With Bobbie and Luke's help, Roy eventually found the evidence to take down corrupt supervisor Larkin, and Bobbie and Roy were finally free to be together.

Their life together went on uneventfully (Roy had to rescue Luke several times; Tony questioned the effect on Lucas Bobbie's relationship with an ex-con might have; Bobbie, not knowing Roy was trying to pay off Mike Corbin's gambling debts, feared Roy was working for Sonny when she saw Roy having meetings with Sorel; Bobbie had to deal with Carly's various crises) until December 2000, when Bobbie found a letter from a woman named Melissa in Roy's apartment. Roy claimed Larkin must have put the letter in there, but he refused to report a break-in. After lying to Roy, Bobbie went to Chicago to visit Melissa. Melissa was a surgical nurse, with a deceased brother named Leo who had run a club with Roy. Bobbie went to see Melissa again with more questions. Roy eventually found out Bobbie had lied to him, but forgave her. Shortly after, Melissa moved to Port Charles, joined the nursing staff, and was with Roy at every turn. Bobbie, increasingly edgy and jealous, misplaced files and accused Melissa of the deed. Melissa quit her job, but after a few more confrontations with Bobbie, changed her mind and began fighting back.

Bobbie was hysterical when beloved son Lucas suddenly became near-death from a mysterious illness. Roy tried his best to stay true to Bobbie. Meanwhile, Carly begged him to turn Sonny into the feds, hoping Sonny would agree to witness protection. Roy agreed, but the plan backfired on Carly when Sonny refused to cooperate, then dumped her after he learned of her part in the sting. When Bobbie heard, she flew into a rage, accusing Roy of destroying Carly's happiness. She broke off her relationship with him, shutting out his every attempt to explain, and finally telling him she had set Melissa up with the files. Despite this, Bobbie refused his several attempts at reconciliation. Finally, she softened, and they parted as friends. The only bright spot in Bobbie's life at this time was Lucas' rapid recovery. Unbeknownst to her, Lucas had been poisoned by Helena's puppet, Lucky, and Tony had agreed to her demands in exchange for the cure. Unfortunately, Helena's demands included Tony helping Helena bring back her son Stavros from a frozen state. Helena and Stavros then terrorized various PC residents before a final showdown in Helena's lab underneath GH. Bobbie was taken hostage during the event and Roy and Scott worked to rescue her along with several other hostages. Helena and Stavros were finally defeated and life returned to normal.

In early 2002, Bobbie and Scott rekindled their relationship after Scott and Laura parted ways. Around this time, Carly was presumed dead after driving her car off of a cliff. Bobbie was devastated and was in denial over the situation... until a body believed to have been Carly's was found in the harbor. At Carly's memorial, guess who the surprise guest was? None other than Carly Corinthos! Bobbie and Scott's relationship continued until Scott began using unscrupulous tactics to win the District Attorney election. Scott began harassing Carly for information on Alexis Davis, the candidate running against him, and that was what fizzled the relationship between the two. Bobbie laid low for a while and spent much of her time trying to keep Lucas in line. He wasn't doing well in school but they later learned that he had dyslexia.

In 2003, Carly announced that she was pregnant to family and friends. On the dark side of things, various conflicts put Carly's pregnancy in jeopardy on many occasions and caused reasons for friends and family to worry. In April, Carly fell through ice while walking Michael off of a frozen pond. In June, Carly was kidnapped by psychotic Ric Lansing (who wanted to present Carly's baby to his wife, Liz, who had just miscarried theirs). In July, a captive Carly accidentally electrocuted herself while trying to communicate with Jason from the panic room. These conflicts affected Sonny the most; towards the end of Carly's pregnancy, Sonny was so worried that something would happen to Carly and the unborn baby that he practically forced Carly to leave a baby shower Bobbie threw for her (where she was surrounded by her family). During a thunderstorm, Carly was looking over a house and was at the top of the stairs when she fell down them and went into labor. Luckily, Lorenzo Alcazar (who had grown obsessed with Carly) was there to help Carly. Lorenzo was helping Carly through labor when Sonny burst in, and, thinking that Lorenzo was harming Carly (because she was experiencing labor pains and screaming), shot him. The bullet went through Lorenzo and hit Carly in the head. Carly gave birth to a baby boy before passing out. She was quickly rushed to the hospital. There, Carly remained in a coma for several weeks. Bobbie wanted to take her grandkids home with her. But Sonny told her that Jason and Courtney could take care of them until Carly finally recovered. Carly did recover, but confided in Bobbie that her feelings for everyone around her were buried beneath the dream sequences she had during her coma. Bobbie did her best to support her daughter in her recovery. Carly finally regained the memory of her feelings for her loved ones a few weeks later.

In 2004, there was a huge fire at the Port Charles Hotel that trapped some of Bobbie's loved ones. Though Bobbie was thankful that Carly and Luke made it out of the fire alive, she was saddened to learn that Scott ended up dying in it. She later found out that he was alive and on the run from Internal Affairs. Bobbie was not happy when Carly started asking more and more questions about her biological father. Bobbie gently urged Carly to drop it, but when she didn't, Bobbie strongly told Carly to stop asking and trying to hurt her. So Carly stole Bobbie's diary and found several entries referencing a man as "J.D." When Bobbie found out, she went to Sonny and implored him to stop Carly's search for her father. He agreed but then told Carly that the best way to get information from Bobbie was to keep her guard down. Sensing that Carly wouldn't stop, Bobbie hired a man to steal the diary back. Carly continued her search by looking through Ruby's old things from the days of the brothel. Carly's search led her to a powerful prosecutor in New York named John Durant.

Bobbie wasn't too happy when Durant chose to move to Port Charles, but she was soon up to it in her eyeballs when she learned that Laura was still alive. Skye learned this information as well, but when she was in a car accident on her way to tell Luke, Bobbie kept Skye sedated so that he wouldn't learn the truth, but finally confessed herself, and told Luke she hadn't wanted him to suffer any more pain. When Carly learned that Michael was murdered, Bobbie was there for her daughter, but was relieved when it was discovered that Michael was alive and well, but had been kidnapped by his biological father, AJ Quartermaine. Shortly after, Durant was shot while in the hospital, and when Bobbie's actions in surgery saved his life but left him temporarily paralyzed, he sued the hospital. Luckily, Durant eventually dropped the lawsuit, but Lucas dropped another bombshell on Bobbie when he told her that he was gay.

Bobbie was devastated when, during the encephalitis plague that hit Port Charles in 2006, Tony was one of the worst hit by the disease and died.

Bobbie welcomed both Luke's son Ethan and Carly's daughter Josslyn into the family. In 2010, she helped Alexis Davis and her daughter, Kristina, after Kristina was abused by her boyfriend. Afterwards, Bobbie moved to Seattle, Washington to be near Lucas but she returned to Port Charles in 2013 to celebrate the news that she was going to be an aunt again. Lulu and her husband Dante were expecting a child via their surrogate Maxie Jones. Her visit was not the joyous occasion she had anticipated after Lulu was kidnapped and Nikolas Cassadine was shot. Bobbie offered her support to Laura and Luke as they awaited news about Lulu.

Bobbie consoled her old friend and former flame Scott Baldwin while his fiancée Laura joined Luke to search for Lulu. Scott stayed in Port Charles to look after Nikolas per Laura's request. While Bobbie was in town, she attended the Nurses Ball but was called back to work in Seattle the following day. As she waited to board the plane, she ran into Noah Drake and he announced that he would be joining her on staff at Seattle General.

Several months later, Bobbie returned to Port Charles to attend Patrick Drake's wedding to Sabrina Santiago. She had planned to go with Noah Drake, the man she was dating, but a last minute surgery prevented Noah from accompanying her. However, Bobbie never made it to the wedding. Instead, she happened upon Jerry Jacks and he took at knifepoint to be his hostage. Jerry planned to exchange Bobbie for the Polonium 210 cure which Luke possessed. Luke managed to free Bobbie and prevent Jerry from obtaining the treatment.

Bobbie returned to Seattle and discovered that Noah had reconnected with his former flame Anne Logan in her absence. She was disappointed with how things turned out but her focus was on her family in Port Charles after she learned that Carly had disappeared. Although Carly was rescued from Heather Webber's clutches and revealed to be safe, Lucas arrived in town and stayed. Bobbie wanted Lucas to leave before he learned that his biological father, organized crime boss Julian Jerome, was alive. Bobbie hoped that Julian would never discover that he had a son. However, the truth came out and Lucas and Julian were curious about one another. To Bobbie's dismay, Lucas offered Julian the opportunity to be a part of his life.

Bobbie's fears regarding Julian's involvement in her son's life were confirmed after Lucas was shot while dining with Julian. As Lucas recovered from a critical gunshot wound and subsequent surgery, Bobbie kept vigil over her son while she blamed Julian for placing him in danger. After Lucas was released from the hospital, Bobbie reconnected with Scott Baldwin and they became lovers. She was aware that Scott still had feelings for Lucy Coe and she engaged in a verbal and physical altercation with Lucy over Scott. The women demanded that Scott chose between them.